Table 1

Evaluation of the aqueous solubility (μg/mL, n = 6) of different benzimidazole (BZD) compounds with or without hydroxypropyl-ß-cyclodextrin (HPßCD) (10%) at different pHs (1.2 or 7.4)
BZD compound pH 1.2 pH 7.4
With HPßCD Without HPßCD With HPßCD Without HPßCD
Albendazole 921.1 ± 347.3 406.1 ± 53.4* 43.0 ± 8.3 4.6 ± 1.3*
Albendazole sulphoxide 6637.7 ± 1370.2 3818.6 ± 202.1* 871.9 ± 129.3 83.6 ± 7.6*
Mebendazole 436.7 ± 47.4 20.5 ± 5.0* 43.0 ± 8.3 4.6 ± 1.3*
Oxfendazole 1902.5 ± 605.8 419.7 ± 29.2* 348.1 ± 46.8 5,5 ± 1.1*
Flubendazole 2251.7 ± 551.5 29.6 ± 2.8* 163.8 ± 119.7 5.8 ± 7.0*

*At each pH value (1.2 or 7.4), significantly different from the solubility obtained in the presence of HPßCD at P < 0.05.

Ceballos et al.

Ceballos et al. BMC Veterinary Research 2012 8:71   doi:10.1186/1746-6148-8-71

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