Email updates

Keep up to date with the latest news and content from BMC Veterinary Research and BioMed Central.

Open Access Highly Accessed Case report

Porencephaly and cortical dysplasia as cause of seizures in a dog

Gisele Fabrino Machado*, Maria-Gisela Laranjeira, Augusto Schweigert and Guilherme Dias de Melo

Author affiliations

Department of Animal Clinics, Surgery and Reproduction, UNESP - Univ Estadual Paulista, College of Veterinary Medicine, Rua Clóvis Pestana, 793, Araçatuba, SP, CEP 16050-680, Brazil

For all author emails, please log on.

Citation and License

BMC Veterinary Research 2012, 8:246  doi:10.1186/1746-6148-8-246

Published: 27 December 2012

Abstract

Background

Seizures are a common problem in small animal neurology and it may be related to underlying diseases. Porencephaly is an extremely rare disorder, and in Veterinary Medicine it affects more often ruminants, with only few reports in dogs.

Case presentation

A one-year-old intact male Shih-Tzu dog was referred to Veterinary University Hospital with history of abnormal gait and generalized tonic-clonic seizures. Signs included hypermetria, abnormal nystagmus and increased myotatic reflexes. At necropsy, during the brain analysis, a cleft was observed in the left parietal and occipital lobes, creating a communication between the subarachnoid space and the left lateral ventricle, consistent with porencephaly; and also a focal atrophy of the caudal paravermal and vermal portions of the cerebellum. Furthermore, the histological examination showed cortical and cerebellar neuronal dysplasia.

Conclusions

Reports of seizures due to porencephaly are rare in dogs. In this case, the dog presented a group of brain abnormalities which per se or in assemblage could result in seizure manifestation.

Keywords:
Brain; Canine; Central nervous system diseases; Cerebellum; Hippocampus; Neuropathology