Table 6 |
||||
Effect of analgesic treatment on dog activity measured using an accelerometer | ||||
ABT-116 (n=13) | Carprofen (n=11) | Tramadol (n=12) | Placebo (n=12) | |
Total activity | 9.7 ± 24.2 | 2.7 ± 9.9 | −6.6 (−22.5, 36.9)^{a} | −1.2 ± 18.4 |
Statistical Power | 0.24 | 0.10 | ||
Sample Size for Power > 0.8 | n = 59 | n = 204 | ||
Daytime activity | 5.8 ± 25.2 | 5.5 ± 11.3 | −4.9 (−22.6, 37.8)^{a} | −0.5 ± 18.1 |
Statistical Power | 0.11 | 0.16 | ||
Sample Size for Power > 0.8 | n = 185 | n = 93 | ||
Nighttime activity | 58.4 ± 97.4** | −23.4 ± 23.8** | 3.0 ± 38.7^{b} | −4.3 ± 44.8 |
Statistical Power | 0.84 | 0.3 | 0.09 | |
Sample Size for Power > 0.8 | N/A | n = 41 | n = 275 |
Note: Daytime activity - 6 am to 10 pm; Nighttime activity - 10 pm to 6 am. Data represent percentage change in Week 3 of the trial, compared with the baseline week. Power analysis results compare each treatment group with placebo. Significance of changes in activity from baseline to end of the trial is indicated as follows: ** - P ≤ 0.01.^{a}Data for Total activity and Daytime activity in the Tramadol group were not normally distributed. ^{b}One dog in Tramadol group was excluded from nighttime activity analysis because the owner removed the accelerometer during this period, so n = 11 in this cell.
Malek et al.
Malek et al. BMC Veterinary Research 2012 8:185 doi:10.1186/1746-6148-8-185