Table 2

Plasma concentrations of ABT-116, carprofen, tramadol, and placebo before and after the first and last doses of the treatment period
Treatment group Trial day 8 Trial day 22
Before dosing 3 hours after dosing n Before dosing 3 hours after dosing n
ABT-116 0 ± 0 569 ± 294 12# 1,277 ± 644 1,589 ± 700*** 12#
ABT-116 metabolite 0 ± 0 115 ± 63 11# 592 ± 256 538 ± 244*** 11#
Carprofen 0 ± 0 3,386 ± 2,282 11# 3,752 ± 2,211 4,779 ± 2,789 11#
Tramadol 0.0 ± 0.0 39.3 ± 35.3 11# 0.6 ± 1.9 7.1 ± 8.8** 11#

Note: All values represent mean ± standard deviation in ng/ml. n – sample number. #One dog in the treatment group was excluded because high drug concentrations were detected in the pre-treatment sample and low concentrations in one or more post-treatment samples. ABT-116, Carprofen, and Tramadol were not detected in any plasma sample from the Placebo group. Significance of changes in plasma drug concentrations from post-treatment sample on Day 8 is indicated as follows: ** - P < 0.01; *** - P < 0.001.

Malek et al.

Malek et al. BMC Veterinary Research 2012 8:185   doi:10.1186/1746-6148-8-185

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