Table 3

Up/down-regulated genes in macrophages grown as a co-culture with canine mammary cancer cells

No

Fold change

Gene symbol

Gene name


1

↑5.78

ABCC5

ABCC5


2

↑3.17

ANXA2

Annexin A2


3

↑3.22

ASPM

Abnormal spindle-like microcephaly-associated protein homolog


4

↑3.0

BGN

Biglycan


5

↑5.83

CAV1

Caveolin-1


6

↑4.04

CAV2

Caveolin-2


7

↑3.47

CCL20

CCL20


8

↑3.15

COL1A1

Collagen alpha-1(I) chain


9

↑4.51

CSF2

Granulocyte-macrophage colony-stimulating factor


10

↑4.28

CXCL10

C-X-C motif chemokine 10


11

↑4.06

EGFR

EGFR


12

↑4.66

FZD6

Frizzled-6


13

↑4.29

GATA6

GATA6


14

↑3.79

IL12A

Interleukin-12 subunit alpha


15

↑3.63

IL13RA2

Interleukin-13 receptor alpha-2 chain


16

↑5.39

MMP3

Stromelysin-1


17

↑4.58

MYC

Myc proto-oncogene protein


18

↑3.51

OAT

OAT


19

↑6.54

PFKM

6-phosphofructokinase, muscle type


20

↑3.86

PTPLA

Protein-tyrosine phosphatase-like member A


21

↑3.36

RAD51

DNA repair protein RAD51 homolog 1


22

↑4.86

RHPN2

Rhophilin-2


23

↑3.05

RPL23

60S ribosomal protein L23


24

↑3.1

RPS17

40S ribosomal protein S17


25

↑3.54

RPS18

40S ribosomal protein S18


26

↑4.87

UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats


27

↑5.11

Wnt5b

wingless-type MMTV integration site family member 5b


28

↑3.78

Wnt7a

wingless-type MMTV integration site family member 7a


29

↑4.51

Wnt7b

wingless-type MMTV integration site family member 7b


30

↑4.11

YES1

Proto-oncogene tyrosine-protein kinase Yes


31

↓3.63

ANPEP

Aminopeptidase N


32

↓3.27

APOE

Apolipoprotein E


33

↓5.73

C5AR1

C5a anaphylatoxin chemotactic receptor


34

↓5.24

CCL13

C-C motif chemokine 13


35

↓3.33

CCL2

C-C motif chemokine 2


36

↓3.36

CCR1

CCR1


37

↓3.73

CCR5

C-C chemokine receptor type 5


38

↓3.66

CD86

CD86


39

↓3.1

CTSK

Cathepsin K


40

↓3.08

CXCR7

C-X-C chemokine receptor type 7


41

↓3.84

DHDH

dehydrogenase


42

↓4.1

EDNRB

Endothelin B receptor


43

↓4.14

HTR7

HTR7


44

↓3.47

IL18

Interleukin-18


45

↓3.15

IL1B

Interleukin-1 beta


46

↓3.1

KCNJ2

Inward rectifier potassium channel 2


47

↓3.61

MMP9

Matrix metalloproteinase-9


48

↓4.72

MYH7

Myosin-7


49

↓4.19

OR04A01

olfactory receptor


50

↓3.64

PDPN

Podoplanin


51

↓3.04

SLC11A1

Natural resistance-associated macrophage protein 1


52

↓3.08

SLC46A2

Thymic stromal cotransporter homolog


53

↓4.09

SLC8A1

Sodium/calcium exchanger 1


54

↓3.15

TLR2

Toll-like receptor 2


55

↓3.11

TLR4

Toll-like receptor 4


The list of up- (↑) and down- (↓) regulated genes in macrophages grown as co-culture with canine mammary cancer cells. The unpaired t-test with Benjamin-Hochberg FDR < 5% (false discovery rate) correction (with p value cut-off < 0.01) (Gene Spring, Agilent, USA) and further PANTHER analysis were conducted

Król et al. BMC Veterinary Research 2012 8:16   doi:10.1186/1746-6148-8-16

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