Table 2

Up/down-regulated genes in canine mammary cancer cell lines grown as co-culture with macrophages

No.

Fold change

Gene symbol

Gene name


1

↑3.25

ANPEP

Aminopeptidase N


2

↑3.83

ATP6V0E1

V-type proton ATPase subunit e 1


3

↑4.98

C5AR1

C5a anaphylatoxin chemotactic receptor


4

↑4.86

CCL2

C-C motif chemokine 2


5

↑5.23

CCL3

C-C motif chemokine 3


6

↑4.28

CCL4

C-C motif chemokine 4


7

↑3.99

CCL5

C-C motif chemokine 5


8

↑3.91

CCL8

C-C motif chemokine 8


9

↑3.03

CCR1

CCR1


10

↑3.66

CCR5

C-C chemokine receptor type 5


11

↑4.47

CD163

Soluble CD163


12

↑3.55

CD40

Tumor necrosis factor receptor superfamily member 5


13

↑4.89

CD80

CD80


14

↑4.31

CD86

CD86


15

↑3.38

COX17

Cytochrome c oxidase copper chaperone


16

↑3.62

CSF2

Granulocyte-macrophage colony-stimulating factor


17

↑3.53

CSF3

Granulocyte colony-stimulating factor


18

↑3.68

CSF1R

Colony stimulating factor receptor 1


19

↑3.09

CTSC

Dipeptidyl-peptidase 1 light chain


20

↑5.06

CTSK

Cathepsin K


21

↑5.92

CTSS

Cathepsin S


22

↑3.5

CXCR7

C-X-C chemokine receptor type 7


23

↑3.26

DLA-64

DLA-64


24

↑3.26

EMR1

EMR1


25

↑3.31

FTH1

Ferritin heavy chain


26

↑3.1

FTL

Ferritin light chain


27

↑5.25

IL1A

Interleukin-1 alpha


28

↑5.07

IL1B

Interleukin-1 beta


29

↑3.45

IL6

Interleukin-6


30

↑5.6

IL8

Interleukin-8


31

↑3.09

MMP9

Matrix metalloproteinase-9


32

↑4.83

MX1

Interferon-induced GTP-binding protein Mx1


33

↑3.34

NPC2

Epididymal secretory protein E1


34

↑3.19

OOEP

Oocyte-expressed protein


35

↑3.6

PLA2G7

Platelet-activating factor acetylhydrolase


36

↑3.23

PSAP

Pulmonary surfactant-associated protein A


37

↑4.84

PSMB8

Proteasome subunit beta type-8


38

↑3.57

PSMB9

Proteasome subunit beta type


39

↑3.74

PTGES

Prostaglandin E synthase


40

↑3.35

SLAMF1

Signaling lymphocytic activation molecule


41

↑3.34

SYK

SYK


42

↑4.64

TLR2

Toll-like receptor 2


43

↑3.55

TLR4

TLR4


44

↓3.11

RXRB

Retinoic acid receptor RXR-beta


45

↓3.17

SLC5A3

Sodium/myo-inositol cotransporter


46

↓3.06

MSX2

Homeobox protein MSX-2


47

↓5.17

KRT13

Keratin 13


The list of up- (↑) and down- (↓) regulated genes in canine mammary cancer cell lines grown as co-culture with macrophages. The unpaired t-test with Benjamin-Hochberg FDR < 5% (false discovery rate) correction (with p value cut-off < 0.01) (Gene Spring, Agilent, USA) and further PANTHER analysis were conducted

Król et al. BMC Veterinary Research 2012 8:16   doi:10.1186/1746-6148-8-16

Open Data