Table 1

Dose acceptance and tolerability in cats subjected to a fortnightly dose escalation regimen of Lantharenol® (Study 1)

Study group

Dose of Lantharenol® (g/kg body weight)

Lantharenol® content in feed original substance1 (g/kg)

Lantharenol® content in complete feed2

(g/kg)

Daily consumption of Lantharenol® 3 (g/day)

Days of administration

No. of cats accepting/not accepting the feed

Signs of intolerability


A

0

0

0

0

63

5/0

None


B

0

0

0

0

14

10/0

None

B

0.125

2.7

10.2

0.4

14

10/0

None

B

0.250

5.4

20.5

0.8

14

10/0

None

B

0.500

10.8

41.8

1.5

14

10/0

None

B

1.000

22.1

84.4

3.1

14

9/14

None

B

2.000

44.5

170.2

6.2

45

7/3

Vomiting


The daily consumption, number of treatment days, number of cats accepting the feed and signs of intolerability observed were compared between a Lantharenol treated group (B; N = 10) and a negative control group (A; N = 5).

1 IAMS adult, rich in lamb, 24% dry matter

2 Complete feed is calculated by multiplying dry matter by the factor 1.12

3 Group means

4 One cat left 25% of its feed on 2 of 14 days

5 The highest dose of Lantharenol® was administered for 2 days, withdrawn for 2 days and then again given for 2 other days (re-challenge)

Schmidt et al. BMC Veterinary Research 2012 8:14   doi:10.1186/1746-6148-8-14

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