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Open Access Highly Accessed Research article

Tolerability and efficacy of the intestinal phosphate binder Lantharenol® in cats

Bernard H Schmidt1*, Ute Dribusch1, Peet C Delport2, Jürgen M Gropp3 and F Josef van der Staay4

Author Affiliations

1 Bayer Animal Health GmbH, Global Drug Discovery & Development, Building 6700, 51368 Leverkusen, Germany

2 ClinVet International Ltd, Bloemfontein, Republic of South Africa

3 Faculty of Veterinary Medicine, University of Leipzig, Germany

4 Emotion and Cognition Group, Farm Animal Health, University Utrecht, The Netherlands

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BMC Veterinary Research 2012, 8:14  doi:10.1186/1746-6148-8-14

Published: 6 February 2012

Abstract

Background

Tolerability and efficacy of the intestinal phosphate binder Lantharenol® (lanthanum carbonate octahydrate) were tested in two prospective, randomized and negative controlled laboratory studies with healthy adult cats fed commercial maintenance diets non-restricted in phosphorus. In the first study, the maximal tolerated dose was determined. Starting from a dose of 0.125 g/kg body weight mixed with the daily feed ration, the dose of Lantharenol® was doubled every other week until signs of intolerability were observed (N = 10 cats compared to 5 untreated controls). In the second study, the effects of feed supplementation for two weeks with approximately 2, 6, and 20% of the maximal tolerated dose on phosphorus excretion patterns and balance were assessed (N = 8 cats per group).

Results

Lantharenol® was found to be safe and well tolerated up to the dose of 1 g/kg bodyweight, corresponding to a concentration of 84 g Lantharenol®/kg complete feed, defined as dry matter with a standard moisture content of 12%. Feed supplementation for two weeks with approximately 2-20% of this dosage (i.e., 1.6, 4.8, and 16 g/kg complete feed) resulted in a shift from urinary to faecal phosphorus excretion. Apparent phosphorus digestibility was dose-dependently reduced compared to the control group fed with diet only (N = 8).

Conclusions

The feed additive was well accepted and tolerated by all cats. Therefore, Lantharenol® presents a well tolerated and efficacious option to individually tailor restriction of dietary phosphorus as indicated, for instance, in feline chronic kidney disease.