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Open Access Highly Accessed Research article

A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody

Mirjam TW van der Sluijs1, Eva M Kuhn2 and Birgit Makoschey3*

Author Affiliations

1 Virological R&D Department, Intervet International b.v., Wim de Körverstraat 35, NL-5831 AN, Boxmeer, the Netherlands

2 Quality Management Biologicals Department, Intervet International b.v., Wim de Körverstraat 35, NL-5831 AN, Boxmeer, the Netherlands

3 Global Ruminant Business Unit, Intervet International b.v., Wim de Körverstraat 35, NL-5831 AN, Boxmeer, the Netherlands

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BMC Veterinary Research 2010, 6:2  doi:10.1186/1746-6148-6-2

Published: 11 January 2010

Abstract

Background

The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV) - Parainfluenaza type 3 (PI3) - Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study.

Results

As expected the single vaccination did not have any effect on the decline of BRSV-specific neutralising or ELISA antibody. The cellular immune system was however primed by the vaccination. In the vaccinated group virus excretion with nasal discharge was reduced, less virus could be re-isolated from lung tissues and the lungs were less affected.

Conclusions

These results indicate that a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves. It can be speculated that the level and duration of protection will improve after the second dose of vaccine is administered. A two-dose basic vaccination schedule is recommended under field conditions.