Table 3 |
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|
Vacuolation scores for each neuroanatomical area in each group of AHQ/AHQ cases |
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|
Mean vacuolation score (± SD) |
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|
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|
Area Code |
Neuroanatomical area |
Atypical Primary challenge |
Atypical Sub-passage |
Classical scrapie |
Ovine BSE |
|
|
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|
(n = 4) |
(n = 2) |
(n = 3) |
(n = 5) |
||
|
|
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|
1 |
Dorsal nucleus of the vagus |
0.00 (± 0.00) |
0.00 (± 0.00) |
2.33 (± 0.58) |
3.20 (± 0.84) |
|
|
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|
2 |
Hypoglossal nucleus |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.60 (± 0.55) |
|
|
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|
3 |
Reticular formation |
0.00 (± 0.00) |
0.00 (± 0.00) |
2.66 (± 0.58) |
3.00 (± 0.71) |
|
|
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|
4 |
Midline raphe (caudal) |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.66 (± 0.58) |
1.00 (± 0.82) |
|
|
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|
5 |
Accessory cuneate nucleus |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
1.00 (± 0.71) |
|
|
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|
6 |
Olivary nuclei |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.33 (± 0.58) |
0.00 (± 0.00) |
|
|
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|
7 |
Vestibular complex |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
|
|
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|
8 |
Cochlear nucleus |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
|
|
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|
9 |
Nucleus of the spinal tract of the trigeminal nerve |
0.00 (± 0.00) |
0.00 (± 0.00) |
1.00 (± 1.00) |
1.80 (± 0.84) |
|
|
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|
10 |
Midline raphe (rostral) |
0.00 (± 0.00) |
0.00 (± 0.00) |
2.33 (± 0.58) |
0.67 (± 0.58) |
|
|
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|
11 |
Cerebellar vermis - nodulus |
1.00 (± 0.82) |
2.00 (± 1.41) |
0.00 (± 0.00) |
0.25 (± 0.50) |
|
|
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|
12 |
Cerebellar vermis -excluding nodulus |
1.75 (± 1.26) |
3.00 (± 0.00) |
0.00 (± 0.00) |
0.00 (± 0.00) |
|
|
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|
13 |
Central grey matter |
0.00 (± 0.00) |
0.00 (± 0.00) |
2.33 (± 0.58) |
1.60 (± 0.55) |
|
|
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|
14 |
Red nucleus |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.33 (± 0.58) |
0.00 (± 0.00) |
|
|
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|
15 |
Substantia nigra |
0.50 (± 0.58) |
0.00 (± 0.00) |
3.66 (± 0.58) |
1.80 (± 1.30) |
|
|
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|
16 |
Lateral geniculate nucleus |
0.00 (± 0.00) |
0.00 (± 0.00) |
0.66 (± 0.58) |
0.20 (± 0.45) |
|
|
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|
17 |
Dorsomedial thalamic nuclei |
0.05 (± 0.58) |
0.50 (± 0.71) |
3.00 (± 0.00) |
1.40 (± 1.14) |
|
|
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|
18 |
Ventrolateral thalamic nuclei |
1.00 (± 0.00) |
0.00 (± 0.00) |
1.66 (± 0.58) |
0.00 (± 0.00) |
|
|
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|
19 |
Hypothalamus |
0.00 (± 0.00) |
0.00 (± 0.00) |
3.33 (± 0.58) |
1.80 (± 0.84) |
|
|
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|
20 |
Head of the caudate nucleus |
2.50 (± 1.00) |
3.00 (± 0.00) |
0.66 (± 1.15) |
1.20 (± 0.84) |
|
|
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|
21 |
Nucleus accumbens |
1.00 (± 0.82) |
2.00 (± 1.41) |
2.00 (± 2.00) |
0.40 (± 0.55) |
|
|
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|
22 |
Frontal cortex |
2.25 (± 0.96) |
3.00 (± 1.41) |
0.00 (± 0.00) |
0.00 (± 0.00) |
|
|
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|
See also Figure 1. |
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|
Simmons et al. BMC Veterinary Research 2010 6:14 doi:10.1186/1746-6148-6-14 |
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