Table 2

Linkage data between the merle phenotype and CFA10 markers. List of the CFA10 genotyped markers in the sub-pedigree (left), the complete pedigree (middle) and all the studied pedigrees (right), with their two point Lod scores and recombination fractions (θ). All markers were selected from CanFam 1.0 sequence draft except FH2293 and C10769 taken from Guyon et al.[13]. The markers are ordered in the table from the centromere to the telomere. a markers flanking the SOX10 gene. Values in bold correspond to the highest Lod scores obtained in the three conditions.

Two point Lod scores values


θ at Lod max

Lod scores at θ


Gene/Marker names

Marker Position (in bp)

θ

Lod max

0.001

0.01

0.05

0.1

0.15

0.2

0.3


Lod scores in the sub-pedigree

CFA10.1

3,109459–3,109703

0.00

6.32

6.31

6.22

5.79

5.23

4.64

4.02

2.68

CFA10.2

3,150322–3,150695

0.00

6.92

6.91

6.82

6.37

5.78

5.16

4.50

3.05

CFA10.3

3,169429–3,169640

0.00

3.01

3.01

2.95

2.72

2.42

2.10

1.76

1.06

CFA10.4

3,452451–3,452757

0.04

5.94

4.82

5.71

5.90

5.55

5.04

4.44

3.04

CFA10.5 c

3,533969–3,534312

0.00

6.92

6.91

6.81

6.35

5.73

5.09

4.40

2.90

CFA10.6

4,050670–4,050915

0.00

3.01

3.01

2.96

2.74

2.46

2.17

1.86

1.20

CFA10.7

4,901919–4,902276

0.00

7.23

7.21

7.11

6.65

6.04

5.39

4.71

3.20

CFA10.8

6,938580–6,938928

0.00

7.23

7.21

7.11

6.65

6.04

5.39

4.71

3.20

CFA10.9

8,539383–8,539710

0.50

0.00

-20.08

-11.15

-5.16

-2.85

-1.68

-0.98

-0.31

CFA10.10

9,459108–9,459324

0.07

2.62

1.21

2.15

2.60

2.57

2.40

2.16

1.52

CFA10.11

10,599594–10,599989

0.04

5.08

3.91

4.82

5.07

4.79

4.35

3.84

2.64

CFA10.12

12,963916–12,964094

0.15

2.55

-4.49

-0.58

1.79

2.43

2.55

2.44

1.83

CFA10.13

13,290922–13,291305

0.18

0.75

-2.99

-1.03

0.21

0.60

0.73

0.74

0.57

CFA10.14

13,687824–13,688059

0.11

3.44

-1.49

1.42

3.09

3.43

3.36

3.10

2.25

CFA10.15

15,287513–15,287805

0.14

2.22

-2.99

-0.06

1.69

2.15

2.21

2.08

1.51

CFA10.16

16,325750–16,325992

0.09

3.67

0.61

2.53

3.55

3.66

3.49

3.19

2.33

CFA10.17

16,883188–16,883575

0.12

2.95

-2.09

0.83

2.53

2.92

2.91

2.72

2.02

CFA10.18

17,574178–17,574420

0.08

3.87

0.91

2.82

3.79

3.84

3.61

3.25

2.31

CFA10.19

18,220318–18,220600

0.10

4.20

-0.58

2.31

3.93

4.20

4.07

3.74

2.75

CFA10.20

19,075239–19,075433

0.12

3.19

-1.79

1.12

2.81

3.17

3.13

2.90

2.10

CFA10.21

19,999011–19,999231

0.26

0.51

-11.69

-5.76

-1.88

-0.50

0.12

0.41

0.47

CFA10.22

21,607022–21,607316

0.10

4.45

-0.28

2.61

4.20

4.45

4.30

3.95

2.90

CFA10.23

21,956041–21,956337

0.10

4.45

-0.28

2.61

4.20

4.45

4.30

3.95

2.90

CFA10.24

23,113457–23,113656

0.25

0.92

-13.18

-6.27

-1.77

-0.17

0.52

0.83

0.85

CFA10.25

24,031569–24,031859

0.10

3.51

-1.19

1.70

3.28

3.51

3.34

2.97

1.93

CFA10.26

25,504535–25,504764

0.14

2.73

-4.19

-0.29

2.05

2.65

2.73

2.57

1.89

CFA10.27

25,930447–25,930692

0.12

1.84

-1.49

0.45

1.58

1.83

1.81

1.67

1.16

CFA10.28

26,491052–26,491288

0.13

1.66

-1.79

0.16

1.32

1.62

1.65

1.56

1.16

CFA10.29

27,391154–27,391817

0.18

2.36

-6.88

-1.98

1.09

2.04

2.33

2.33

1.87

CFA10.30

28,230039–28,230419

0.30

0.69

-18.28

-9.37

-3.47

-1.27

-0.23

0.33

0.69

CFA10.31a

29,232270–29,232511

0.13

3.51

-3.28

0.61

2.90

3.46

3.49

3.27

2.45

CFA10.32a

29,355913–29,355989

0.14

3.09

-3.88

0.02

2.37

2.99

3.08

2.94

2.24

CFA10.33a

29,483066–29,483109

0.13

2.40

-2.69

0.23

1.95

2.37

2.38

2.22

1.58

CFA10.34a

29,826073–29,826290

0.14

2.52

-2.69

0.24

2.00

2.45

2.51

2.38

1.81

CFA10.35a

29,834441–29,834690

0.16

2.74

-6.28

-1.39

1.63

2.51

2.73

2.67

2.08

SOX10

29,856920–29,867728

CFA10.36a

29,861299–29,861547

0.08

3.60

0.61

2.52

3.51

3.58

3.37

3.02

2.10

CFA10.37a

29,868038–29,868267

0.14

3.38

-3.58

0.32

2.67

3.29

3.37

3.21

2.47

CFA10.38a

30,176995–30,177378

0.11

3.65

-1.19

1.71

3.35

3.65

3.55

3.26

2.38

FH2293a

31,696028–31,696274

0.13

3.56

-3.28

0.61

2.93

3.50

3.54

3.34

2.53

C10.769a

36,663349–36,663563

0.18

1.50

-5.99

-2.06

0.42

1.20

1.46

1.49

1.18


Lod scores in the complete pedigree

CFA10.1

3,109459–3,109703

0.00

11.74

11.72

11.54

10.70

9.61

8.46

7.27

4.71

CFA10.2

3,150322–3,150695

0.02

11.97

11.13

11.91

11.63

10.64

9.48

8.20

5.38

CFA10.3

3,169429–3,169640

0.00

6.62

6.61

6.50

5.98

5.30

4.60

3.86

2.33

CFA10.4

3,452451–3,452757

0.03

13.82

11.73

13.46

13.65

12.67

11.36

9.88

6.55

CFA10.5 c

3,533969–3,534312

0.02

8.77

7.82

8.65

8.58

7.88

7.01

6.03

3.86

CFA10.6

4,050670–4,050915

0.00

6.92

6.91

6.79

6.24

5.51

4.76

3.99

2.41

CFA10.7

4,901919–4,902276

0.00

15.65

15.63

15.39

14.30

12.88

11.40

9.84

6.54

CFA10.8

6,938580–6,938928

0.02

14.90

14.13

14.87

14.39

13.16

11.72

10.17

6.76

CFA10.9

8,539383–8,539710

0.19

2.48

-14.38

-5.54

0.02

1.78

2.38

2.47

1.89


Lod scores in the complete pedigree plus families

of dachshund, Beauce shepherd and Border collie

CFA10.1

3,109459–3,109703

0.04

10.67

8.43

10.21

10.61

9.91

8.91

7.74

5.09

CFA10.2

3,150322–3,150695

0.04

10.97

8.73

10.51

10.91

10.21

9.21

8.04

5.39

CFA10.3

3,169429–3,169640

0.00

6.02

6.01

5.91

5.44

4.84

4.22

3.56

2.20

CFA10.4

3,452451–3,452757

0.03

14.38

12.33

14.05

14.19

13.15

11.79

10.25

6.83

CFA10.5 c

3,533969–3,534312

0.02

8.77

7.82

8.65

8.58

7.89

7.02

6.05

3.90

CFA10.6

4,050670–4,050915

0.03

6.99

6.01

6.86

6.85

6.23

5.46

4.61

2.82

CFA10.7

4,901919–4,902276

0.00

19.87

19.83

19.52

18.11

16.28

14.37

12.37

8.15

CFA10.8

6,938580–6,938928

0.00

19.57

19.53

19.22

17.82

15.99

14.08

12.09

7.91

CFA10.9

8,539383–8,539710

0.16

4.23

-11.97

-3.16

2.25

3.83

4.22

4.10

3.02


Hédan et al. BMC Veterinary Research 2006 2:9   doi:10.1186/1746-6148-2-9

Open Data