Table 2 |
|||||||||||
|
Linkage data between the merle phenotype and CFA10 markers. List of the CFA10 genotyped markers in the sub-pedigree (left), the complete pedigree (middle) and all the studied pedigrees (right), with their two point Lod scores and recombination fractions (θ). All markers were selected from CanFam 1.0 sequence draft except FH2293 and C10769 taken from Guyon et al.[13]. The markers are ordered in the table from the centromere to the telomere. a markers flanking the SOX10 gene. Values in bold correspond to the highest Lod scores obtained in the three conditions. |
|||||||||||
|
Two point Lod scores values |
|||||||||||
|
|
|||||||||||
|
θ at Lod max |
Lod scores at θ |
||||||||||
|
|
|||||||||||
|
Gene/Marker names |
Marker Position (in bp) |
θ |
Lod max |
0.001 |
0.01 |
0.05 |
0.1 |
0.15 |
0.2 |
0.3 |
|
|
|
|||||||||||
|
Lod scores in the sub-pedigree |
CFA10.1 |
3,109459–3,109703 |
0.00 |
6.32 |
6.31 |
6.22 |
5.79 |
5.23 |
4.64 |
4.02 |
2.68 |
|
CFA10.2 |
3,150322–3,150695 |
0.00 |
6.92 |
6.91 |
6.82 |
6.37 |
5.78 |
5.16 |
4.50 |
3.05 |
|
|
CFA10.3 |
3,169429–3,169640 |
0.00 |
3.01 |
3.01 |
2.95 |
2.72 |
2.42 |
2.10 |
1.76 |
1.06 |
|
|
CFA10.4 |
3,452451–3,452757 |
0.04 |
5.94 |
4.82 |
5.71 |
5.90 |
5.55 |
5.04 |
4.44 |
3.04 |
|
|
CFA10.5 c |
3,533969–3,534312 |
0.00 |
6.92 |
6.91 |
6.81 |
6.35 |
5.73 |
5.09 |
4.40 |
2.90 |
|
|
CFA10.6 |
4,050670–4,050915 |
0.00 |
3.01 |
3.01 |
2.96 |
2.74 |
2.46 |
2.17 |
1.86 |
1.20 |
|
|
CFA10.7 |
4,901919–4,902276 |
0.00 |
7.23 |
7.21 |
7.11 |
6.65 |
6.04 |
5.39 |
4.71 |
3.20 |
|
|
CFA10.8 |
6,938580–6,938928 |
0.00 |
7.23 |
7.21 |
7.11 |
6.65 |
6.04 |
5.39 |
4.71 |
3.20 |
|
|
CFA10.9 |
8,539383–8,539710 |
0.50 |
0.00 |
-20.08 |
-11.15 |
-5.16 |
-2.85 |
-1.68 |
-0.98 |
-0.31 |
|
|
CFA10.10 |
9,459108–9,459324 |
0.07 |
2.62 |
1.21 |
2.15 |
2.60 |
2.57 |
2.40 |
2.16 |
1.52 |
|
|
CFA10.11 |
10,599594–10,599989 |
0.04 |
5.08 |
3.91 |
4.82 |
5.07 |
4.79 |
4.35 |
3.84 |
2.64 |
|
|
CFA10.12 |
12,963916–12,964094 |
0.15 |
2.55 |
-4.49 |
-0.58 |
1.79 |
2.43 |
2.55 |
2.44 |
1.83 |
|
|
CFA10.13 |
13,290922–13,291305 |
0.18 |
0.75 |
-2.99 |
-1.03 |
0.21 |
0.60 |
0.73 |
0.74 |
0.57 |
|
|
CFA10.14 |
13,687824–13,688059 |
0.11 |
3.44 |
-1.49 |
1.42 |
3.09 |
3.43 |
3.36 |
3.10 |
2.25 |
|
|
CFA10.15 |
15,287513–15,287805 |
0.14 |
2.22 |
-2.99 |
-0.06 |
1.69 |
2.15 |
2.21 |
2.08 |
1.51 |
|
|
CFA10.16 |
16,325750–16,325992 |
0.09 |
3.67 |
0.61 |
2.53 |
3.55 |
3.66 |
3.49 |
3.19 |
2.33 |
|
|
CFA10.17 |
16,883188–16,883575 |
0.12 |
2.95 |
-2.09 |
0.83 |
2.53 |
2.92 |
2.91 |
2.72 |
2.02 |
|
|
CFA10.18 |
17,574178–17,574420 |
0.08 |
3.87 |
0.91 |
2.82 |
3.79 |
3.84 |
3.61 |
3.25 |
2.31 |
|
|
CFA10.19 |
18,220318–18,220600 |
0.10 |
4.20 |
-0.58 |
2.31 |
3.93 |
4.20 |
4.07 |
3.74 |
2.75 |
|
|
CFA10.20 |
19,075239–19,075433 |
0.12 |
3.19 |
-1.79 |
1.12 |
2.81 |
3.17 |
3.13 |
2.90 |
2.10 |
|
|
CFA10.21 |
19,999011–19,999231 |
0.26 |
0.51 |
-11.69 |
-5.76 |
-1.88 |
-0.50 |
0.12 |
0.41 |
0.47 |
|
|
CFA10.22 |
21,607022–21,607316 |
0.10 |
4.45 |
-0.28 |
2.61 |
4.20 |
4.45 |
4.30 |
3.95 |
2.90 |
|
|
CFA10.23 |
21,956041–21,956337 |
0.10 |
4.45 |
-0.28 |
2.61 |
4.20 |
4.45 |
4.30 |
3.95 |
2.90 |
|
|
CFA10.24 |
23,113457–23,113656 |
0.25 |
0.92 |
-13.18 |
-6.27 |
-1.77 |
-0.17 |
0.52 |
0.83 |
0.85 |
|
|
CFA10.25 |
24,031569–24,031859 |
0.10 |
3.51 |
-1.19 |
1.70 |
3.28 |
3.51 |
3.34 |
2.97 |
1.93 |
|
|
CFA10.26 |
25,504535–25,504764 |
0.14 |
2.73 |
-4.19 |
-0.29 |
2.05 |
2.65 |
2.73 |
2.57 |
1.89 |
|
|
CFA10.27 |
25,930447–25,930692 |
0.12 |
1.84 |
-1.49 |
0.45 |
1.58 |
1.83 |
1.81 |
1.67 |
1.16 |
|
|
CFA10.28 |
26,491052–26,491288 |
0.13 |
1.66 |
-1.79 |
0.16 |
1.32 |
1.62 |
1.65 |
1.56 |
1.16 |
|
|
CFA10.29 |
27,391154–27,391817 |
0.18 |
2.36 |
-6.88 |
-1.98 |
1.09 |
2.04 |
2.33 |
2.33 |
1.87 |
|
|
CFA10.30 |
28,230039–28,230419 |
0.30 |
0.69 |
-18.28 |
-9.37 |
-3.47 |
-1.27 |
-0.23 |
0.33 |
0.69 |
|
|
CFA10.31a |
29,232270–29,232511 |
0.13 |
3.51 |
-3.28 |
0.61 |
2.90 |
3.46 |
3.49 |
3.27 |
2.45 |
|
|
CFA10.32a |
29,355913–29,355989 |
0.14 |
3.09 |
-3.88 |
0.02 |
2.37 |
2.99 |
3.08 |
2.94 |
2.24 |
|
|
CFA10.33a |
29,483066–29,483109 |
0.13 |
2.40 |
-2.69 |
0.23 |
1.95 |
2.37 |
2.38 |
2.22 |
1.58 |
|
|
CFA10.34a |
29,826073–29,826290 |
0.14 |
2.52 |
-2.69 |
0.24 |
2.00 |
2.45 |
2.51 |
2.38 |
1.81 |
|
|
CFA10.35a |
29,834441–29,834690 |
0.16 |
2.74 |
-6.28 |
-1.39 |
1.63 |
2.51 |
2.73 |
2.67 |
2.08 |
|
|
SOX10 |
29,856920–29,867728 |
||||||||||
|
CFA10.36a |
29,861299–29,861547 |
0.08 |
3.60 |
0.61 |
2.52 |
3.51 |
3.58 |
3.37 |
3.02 |
2.10 |
|
|
CFA10.37a |
29,868038–29,868267 |
0.14 |
3.38 |
-3.58 |
0.32 |
2.67 |
3.29 |
3.37 |
3.21 |
2.47 |
|
|
CFA10.38a |
30,176995–30,177378 |
0.11 |
3.65 |
-1.19 |
1.71 |
3.35 |
3.65 |
3.55 |
3.26 |
2.38 |
|
|
FH2293a |
31,696028–31,696274 |
0.13 |
3.56 |
-3.28 |
0.61 |
2.93 |
3.50 |
3.54 |
3.34 |
2.53 |
|
|
C10.769a |
36,663349–36,663563 |
0.18 |
1.50 |
-5.99 |
-2.06 |
0.42 |
1.20 |
1.46 |
1.49 |
1.18 |
|
|
|
|||||||||||
|
Lod scores in the complete pedigree |
CFA10.1 |
3,109459–3,109703 |
0.00 |
11.74 |
11.72 |
11.54 |
10.70 |
9.61 |
8.46 |
7.27 |
4.71 |
|
CFA10.2 |
3,150322–3,150695 |
0.02 |
11.97 |
11.13 |
11.91 |
11.63 |
10.64 |
9.48 |
8.20 |
5.38 |
|
|
CFA10.3 |
3,169429–3,169640 |
0.00 |
6.62 |
6.61 |
6.50 |
5.98 |
5.30 |
4.60 |
3.86 |
2.33 |
|
|
CFA10.4 |
3,452451–3,452757 |
0.03 |
13.82 |
11.73 |
13.46 |
13.65 |
12.67 |
11.36 |
9.88 |
6.55 |
|
|
CFA10.5 c |
3,533969–3,534312 |
0.02 |
8.77 |
7.82 |
8.65 |
8.58 |
7.88 |
7.01 |
6.03 |
3.86 |
|
|
CFA10.6 |
4,050670–4,050915 |
0.00 |
6.92 |
6.91 |
6.79 |
6.24 |
5.51 |
4.76 |
3.99 |
2.41 |
|
|
CFA10.7 |
4,901919–4,902276 |
0.00 |
15.65 |
15.63 |
15.39 |
14.30 |
12.88 |
11.40 |
9.84 |
6.54 |
|
|
CFA10.8 |
6,938580–6,938928 |
0.02 |
14.90 |
14.13 |
14.87 |
14.39 |
13.16 |
11.72 |
10.17 |
6.76 |
|
|
CFA10.9 |
8,539383–8,539710 |
0.19 |
2.48 |
-14.38 |
-5.54 |
0.02 |
1.78 |
2.38 |
2.47 |
1.89 |
|
|
|
|||||||||||
|
Lod scores in the complete pedigree plus families of dachshund, Beauce shepherd and Border collie |
CFA10.1 |
3,109459–3,109703 |
0.04 |
10.67 |
8.43 |
10.21 |
10.61 |
9.91 |
8.91 |
7.74 |
5.09 |
|
CFA10.2 |
3,150322–3,150695 |
0.04 |
10.97 |
8.73 |
10.51 |
10.91 |
10.21 |
9.21 |
8.04 |
5.39 |
|
|
CFA10.3 |
3,169429–3,169640 |
0.00 |
6.02 |
6.01 |
5.91 |
5.44 |
4.84 |
4.22 |
3.56 |
2.20 |
|
|
CFA10.4 |
3,452451–3,452757 |
0.03 |
14.38 |
12.33 |
14.05 |
14.19 |
13.15 |
11.79 |
10.25 |
6.83 |
|
|
CFA10.5 c |
3,533969–3,534312 |
0.02 |
8.77 |
7.82 |
8.65 |
8.58 |
7.89 |
7.02 |
6.05 |
3.90 |
|
|
CFA10.6 |
4,050670–4,050915 |
0.03 |
6.99 |
6.01 |
6.86 |
6.85 |
6.23 |
5.46 |
4.61 |
2.82 |
|
|
CFA10.7 |
4,901919–4,902276 |
0.00 |
19.87 |
19.83 |
19.52 |
18.11 |
16.28 |
14.37 |
12.37 |
8.15 |
|
|
CFA10.8 |
6,938580–6,938928 |
0.00 |
19.57 |
19.53 |
19.22 |
17.82 |
15.99 |
14.08 |
12.09 |
7.91 |
|
|
CFA10.9 |
8,539383–8,539710 |
0.16 |
4.23 |
-11.97 |
-3.16 |
2.25 |
3.83 |
4.22 |
4.10 |
3.02 |
|
|
|
|||||||||||
|
Hédan et al. BMC Veterinary Research 2006 2:9 doi:10.1186/1746-6148-2-9 |
|||||||||||
