Table 1

Linkage data between the merle phenotype and markers flanking the TYRP1 gene and MITF and PAX3 candidate genes. Two point Lod scores and recombination fractions (θ) between the merle phenotype and the markers flanking TYRP1, MITF and PAX3 genes calculated on the sub-pedigree. a CFA: Canis familiaris chromosome. b Starred markers were selected from the CanFam 1.0 canine sequence draft. Significant exclusions (<-2) are indicated in bold.

θ at Lod score max

Lod scores at θ


CFAa

Gene/Markersb

Gene/Marker Position in bp

θ

Lod score max

0.001

0.01

0.05

0.1

0.15

0.2

0.3


CFA11

TYRP1

34,664779–34,683148

FH2319

35,863893–35,864169

0.5

0.0

-23.083

-13.146

-6.442

-3.802

-2.429

-1.582

-0.661

Ren105l03

39,857761–39,857999

0.5

0.0

-15.888

-8.939

-4.278

-2.471

-1.549

-0.995

-0.417


Ren96j16

22,981531–22,981669

0.5

0.0

-13.194

-8.198

-4.721

-3.24

-2.384

-1.786

-0.963

Ren130E03

22,981511–22,981683

0.5

0.0

-13.194

-8.198

-4.721

-3.24

-2.384

-1.786

-0.963

Ren159M20

23,456266–23,456464

0.5

0.0

-19.789

-11.82

-6.37

-4.141

-2.915

-2.1

-1.061

CFA20

MITF

24,701418–24,735483

Ren100j13

25,668407–25,668570

0.5

0.0

-24.585

-14.621

-7.791

-4.988

-3.442

-2.417

-1.131

Ren178E07

26,911251–26,911383

0.5

0.0

-12.593

-7.605

-4.164

-2.729

-1.923

-1.377

-0.671


Ren105M20

19,606338–19,606486

0.4

0.087

-8.992

-5.016

-2.327

-1.264

-0.709

-0.367

-0.011

Ren67C18

22,361131–22,361265

0.5

0.0

-11.992

-7.012

-3.606

-2.218

-1.462

-0.969

-0.379

Pax3.2*

30,185679–30,186031

0.27

0.147

-9.89

-4.957

-1.763

-0.644

-0.159

0.063

0.137

CFA37

PAX3

31,332182–31,429995

Pax3.1*

31,368786–31,369020

0.5

0.0

-20.085

-11.159

-5.204

-2.924

-1.779

-1.101

-0.418

Ren75L05

31,649572–31,649607

0.5

0.0

-9.294

-5.321

-2.65

-1.605

-1.065

-0.732

-0.36


Hédan et al. BMC Veterinary Research 2006 2:9   doi:10.1186/1746-6148-2-9

Open Data