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Metoclopramide -induced sedation and sleep (loss of righting reflex) in chicks |
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| Metoclopramide (mg/kg, subcutaneously) |
Latency to onset of sedation (minute) |
Latency to onset of sleep (minute) |
Duration of sedation (minute) |
Duration of sleep (minute) |
Recovery time (minute) |
|
|
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| 50 |
19.0 ± 2.2 |
none |
37.2 ± 7.6 |
none |
43.4 ± 7.8 |
| 100 |
8.8 ± 2.5* |
12.2 ± 2.2 |
66.4 ± 5.5* |
43.8 ± 3.5 |
74.6 ± 6.4* |
| 200 |
3.6 ± 0.5* |
6.2 ± 0.5† |
163.4 ± 17.4*† |
158.6 ± 23.3*† |
168.4 ± 16.6*† |
|
Values are mean ± SE of 5 chicks/group. * Significantly different from the 50 mg/kg treatment group, P < 0.05. † Significantly different from the 100 mg/kg treatment group, P < 0.05. A control group of chicks was also treated with physiological saline solution (5 ml/kg, subcutaneously). | |||||
Al-Zubaidy and Mohammad BMC Veterinary Research 2005 1:6 doi:10.1186/1746-6148-1-6 |
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