Table 7

Reported symptoms in ME/CFS prevalent cases according to compliance with Canadian criteria and non-casesa

Current symptoms

Compliance with

Canadian criteria

No

(n = 97)

(%)

Yes

(n = 125)

(%)

Non-case

(n = 122)

(%)


Sleep dysfunction

Unrefreshing sleep

93.8d

100.0b

63.1

Sleep problems

74.2b

97.6 d

56.6


Neurological/Cognitive manifestations

Memory/concentration problems

89.7d

97.6b

54.1

Difficulty thinking

69.1d

93.6 d

42.6

Unexplained muscle weakness

60.8c

88.0 d

41.0

Light/noise sensitivity

44.3b

82.4 d

28.7

Difficulty in understanding things

37.1

77.6 d

32.0

Confusion or disorientation

28.9

78.4 d

26.2


Pain

Pain in two or more joints

89.7d

94.4 d

46.7

Muscle pain

86.6d

95.2 b

48.4

Muscle discomfort

82.5d

93.6 b

48.4

Migratory joint pain

71.1d

87.2 c

40.2

Headaches

51.5c

76.0 d

32.8

Migraine

15.5

39.2 d

21.3


Fatigue/tiredness

Fatigue after exercise (> 24 hours)

52.6b

100.0 d

37.0

Intolerance to exercise

50.5b

84.8 d

34.4

Malaise after exertion (> 24 hours)

41.2b

85.6 d

26.2


Psychological

Anxiety

63.0

88.0 d

56.6

Depression

50.5

75.2 d

41.0


Autonomic

Sweatiness/cold hands and feet

42.3

88.8 d

38.5

Intolerance to be on your feet

38.1b

80.8d

24.6


Immunological

Sore throat

37.1

71.2 d

27.0

Tender glands in the neck/armpits

36.1

73.6 d

27.9

Mild fever or chills

23.7

77.6 d

29.5


aAll cases met the CDC-1994 criteria; P-values are shown for comparisons of proportions of symptoms between cases that do not conform to the Canadian criteria and non-cases; and between cases that conform to Canadian criteria and non-cases. The following symbols show respective P-values: bP < 0.05; cP < 0.005; dP≤0.001; the results comparing ECD with other diagnostic criteria and non-cases are not presented due to small numbers.

Nacul et al. BMC Medicine 2011 9:91   doi:10.1186/1741-7015-9-91

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