Table 2

Genotypic distributions and ORs for the association between five polymorphisms and obesity

Study

N (case/control)

OR [95% CI], P-value


Subtotal

MAF

PHWE

11a

12

22

Additive model

Allelic comparison


rs9939609


Caucasian:

Frayling_a

5,380 (353/5,027)

0.48/0.39

0.513

107/1,879

157/2,407

89/741

1.43 (1.23 to 1.67)

1.43 (1.23 to 1.67)

Frayling_b

3,072 (415/2,657)

0.45/0.37

0.185

132/1,060

193/1,211

90/386

1.36 (1.18 to 1.57)

1.37 (1.18 to 1.59)

Frayling_c

487 (126/361)

0.42/0.38

0.575

45/138

56/175

25/48

1.21 (0.90 to 1.62)

1.21 (0.91 to 1.61)

Frayling_d

623 (200/423)

0.41/0.34

0.447

67/189

101/182

32/52

1.37 (1.07 to 1.75)

1.37 (1.08 to 1.76)

Frayling_e

2,511 (1,588/923)

0.43/0.38

0.625

485/351

847/443

256/129

1.24 (1.10 to 1.40)

1.22 (1.09 to 1.37)

Frayling_f

1,875 (840/1,035)

0.42/0.37

0.547

274/421

427/471

139/143

1.26 (1.10 to 1.44)

1.25 (1.10 to 1.43)

Frayling_g

461 (212/249)

0.47/0.42

0.514

66/82

92/127

54/40

1.25 (0.97 to 1.61)

1.26 (0.97 to 1.63)

Andreasen_a

3,724 (1,045/2,679)

0.45/0.39

0.103

313/993

517/1,309

215/377

1.33 (1.20 to 1.48)

1.32 (1.19 to 1.47)

Andreasen_b

4,671 (2,819/1,852)

0.43/0.39

0.221

911/684

1,385/904

523/264

1.21 (1.11 to 1.31)

1.20 (1.11 to 1.31)

Andreasen_c

377 (104/273)

0.45/0.39

0.076

30/93

55/145

19/35

1.27(0.91 to 1.80)

1.25 (0.90 to 1.72)

Muler

697 (519/178)

0.50/0.44

0.763

140/56

238/86

141/36

1.24 (0.98 to 1.57)

1.26 (0.99 to 1.60)

Price

1,047 (527/520)

0.48/0.36

0.084

152/207

242/257

133/56

1.69 (1.41 to 2.02)

1.69 (1.42 to 2.02)

Peeters

1,367 (1,099/268)

0.46/0.40

0.703

316/94

553/133

230/41

1.28 (1.05 to 1.56)

1.28 (1.05 to 1.55)

Jacobsson_2008

960 (450/510)

0.48/0.42

0.716

133/174

206/244

111/92

1.24 (1.04 to 1.48)

1.25 (1.05 to 1.50)

Legry

3,367 (598/2,769)

0.46/0.41

0.050

171/924

307/1,395

120/450

1.20 (1.05 to 1.36)

1.19 (1.05 to 1.35)

Jacobsson_2009

1,115 (54/1,061)

0.44/0.39

0.218

16/411

29/483

9/167

1.22 (0.83 to 1.80)

1.23 (0.83 to 1.82)

Hinney

926 (484/442)

0.50/0.39

0.690

123/164

241/214

120/64

1.57 (1.30 to 1.90)

1.57 (1.30 to 1.88)

Asian:

Song_AP

240 (77/163)

0.20/0.17

0.409

50/114

23/43

4/6

1.23 (0.76 to 1.97)

1.24 (0.76 to 2.03)

Chang

2,135 (610/1,525)

0.17/0.13

0.355

425/1,158

167/347

18/20

1.38 (1.15 to 1.66)

1.37 (1.14 to 1.5)

Hotta

2,423 (919/1,504)

0.24/0.19

0.393

534/1,005

334/443

51/56

1.37 (1.19 to 1.58)

1.66 (1.31 to 2.11)

Tabara

1,718 (214/1,504)

0.22/0.16

0.438

128/1,063

77/408

9/33

1.54 (1.20 to 1.99)

1.53 (1.19 to 1.95)

Karasawa

2,639 (794/1,845)

0.23/0.20

0.373

477/1,203

271/566

46/76

1.22 (1.06 to 1.41)

1.23 (1.06 to 1.42)

Liu

1,167 (276/891)

0.14/0.11

0.396

201/701

70/181

5/8

1.38 (1.04 to 1.83)

1.36 (1.03 to 1.80)

Li

3,210 (398/2,812)

NA/0.12

NA

NA

NA

NA

0.90 (0.70 to 1.15)

NA

Hispanic:

Song_H

415 (139/276)

0.27/0.31

0.157

75/138

53/107

11/31

0.85 (0.62 to 1.16)

0.84 (0.61 to 1.15

Gonzalez

725 (207/518)

0.45/0.37

0.925

62/203

104/244

41/71

1.38 (1.09 to 1.74)

1.37 (1.09 to 1.73)

Zabena

255 (75/180)

0.52/0.34

1.0

19/78

34/81

22/21

2.04 (1.38 to 3.02)

2.09 (1.42 to 3.07)

African:

Song_B

1,114 (365/749)

0.47/0.45

0.160

113/239

161/351

91/159

1.09 (0.92 to 1.30)

1.10 (0.92 to 1.31)

South American:

Villalobos

788 (364/424)

0.25/0.17

0.598

209/297

127/114

28/13

1.66 (1.31 to 2.11)

1.7 (1.33 to 2.17)

Mixed:

Willer

19,367 (5,261/14,106)

NA

NA

NA

NA

NA

NA

1.25 (1.19 to 1.31)


Total N (rs9939609)

68,856 (21,132/47,724)

Pooled ORs

1.31 (1.25 to 1.37)

1.31 (1.26 to 1.36)


rs1421085


Causian:

Dina_a

3,557 (867/2,690)

0.52/0.41

0.218

200/944

425/1,273

242/473

1.55 (1.39 to 1.73)

1.57 (1.41 to 1.75)

Dina_b

1,678 (699/979)

0.51/0.42

0.896

173/323

334/481

192/175

1.42 (1.24 to 1.63)

1.43 (1.25 to 1.64)

Dina_c

1,001 (482/519)

0.51/0.41

0.205

119/187

233/237

130/95

1.47 (1.24 to 1.75)

1.50 (1.26 to 1.79)

Dina_d

1,018 (504/514)

0.52/0.46

0.051

123/161

235/233

146/120

1.26 (1.07 to 1.49)

1.29 (1.08 to 1.53)

Dina_e

551 (283/268)

0.53/0.40

0.637

62/246

142/343

79/110

1.69 (1.38 to 2.06)

1.67 (1.37 to 2.04)

Peeters

1,367 (1,099/268)

0.48/0.41

0.900

300/93

544/129

255/46

1.31 (1.08 to 1.59)

1.31 (1.09 to 1.59)

Attaoua

248 (119/129)

0.55/0.41

0.585

24/47

58/59

37/23

1.78 (1.24 to 2.54)

1.81 (1.27 to 2.59)

Meyre_FC

1,036 (491/545)

0.49/0.41

0.077

137/197

231/244

123/104

1.31 (1.11 to 1.55)

1.33 (1.12 to 1.59)

Meyre_FA

859 (132/727)

0.51/0.43

0.820

31/238

67/359

34/130

1.42 (1.09 to 1.85)

1.41 (1.09 to 1.84)

Meyre_SA

1,346 (1,028/318)

0.50/0.46

0.055

286/100

460/141

282/77

1.13 (0.96 to 1.34)

1.15 (0.96 to 1.37)

Meyre_GC

1,080 (370/710)

0.55/0.45

0.081

76/227

181/328

113/155

1.47 (1.23 to 1.75)

1.50 (1.25 to 1.79)


Total N (rs1421085)

13,741 (6,074/7,667)

Pooled ORs

1.41 (1.31 to 1.51)

1.43 (1.33 to 1.53)


rs8050136


Caucasian:

Hinney

928 (486/442)

0.50/0.39

0.842

123/165

240/212

123/65

1.58 (1.31 to 1.91)

1.59 (1.32 to 1.91)

Grant_C

2,688 (418/2,270)

0.45/0.39

NA

NA

NA

NA

NA

1.27 (1.09 to 1.47)

Asian:

Song_AP

240 (77/163)

0.20/0.18

0.425

52/111

20/45

5/7

1.09 (0.68 to 1.73)

1.10 (0.67 to 1.78)

Cheung

1,159 (468/691)

0.16/0.12

0.463

326/535

131/149

11/7

1.48 (1.16 to 1.89)

1.46 (1.15 to 1.85)

Liu

1,180 (278/902)

0.15/0.11

0.489

201/716

73/178

4/8

1.43 (1.08 to 1.91)

1.42 (1.07 to 1.87)

Li

3,210 (398/2,812)

NA/0.12

NA

NA

NA

NA

0.91 (0.71 to 1.16)

NA

African:

Song_B

1,114 (365/749)

0.42/0.42

0.454

133/257

161/355

71/137

0.98 (0.82 to 1.17)

0.98 (0.82 to 1.17)

Grant_AA

2,002 (578/1,424)

0.45/0.44

NA

NA

NA

NA

NA

1.05 (0.91 to 1.21)

Mixed:

Thorleifsson

22,277 (13,785/8,492)

NA

NA

NA

NA

NA

NA

1.27 (1.21 to 1.32)


Total N (rs8050136)

34,798 (16,853/17,945)

Pooled ORs

1.22 (0.99 to 1.51)

1.25 (1.13 to 1.38)


rs17817449


Caucasian:

Dina_a [6]

3,548 (873/2,675)

0.49/0.60

0.968

212/948

426/1,288

235/439

1.55 (1.39 to 1.72)

1.55 (1.39 to 1.73)

Dina_b

1,589 (689/900)

0.47/0.59

0.600

164/337

320/489

205/164

1.59 (1.38 to 1.83)

1.60 (1.40 to 1.84)

Dina_c

1,010 (485/525)

0.49/0.60

0.173

120/196

236/237

129/92

1.52 (1.28 to 1.81)

1.55 (1.30 to 1.85)

Dina_d

1,035 (516/519)

0.50/0.55

0.374

138/164

243/246

135/109

1.21 (1.02 to 1.43)

1.22 (1.03 to 1.45)

Dina_e

972 (281/691)

0.46/0.58

0.755

58/231

142/341

81/119

1.65 (1.35 to 2.01)

1.63 (1.34 to 1.99)

Price

1,049 (527/522)

0.49/0.36

0.087

145/205

247/259

135/58

1.72 (1.44 to 2.06)

1.72 (1.44 to 2.05)


Total N (rs17817449)

9,203 (3,371/5,832)

Pooled ORs

1.53 (1.40 to 1.67)

1.54 (1.41 to 1.68)


rs1121980


Caucasian:

Hinney

926 (484/442)

0.53/0.41

0.694

104/153

247/218

133/71

1.66 (1.37 to 2.01)

1.64 (1.37 to 1.97)

Renstrom

1,723 (353/1,370)

NA

NA

NA

NA

NA

NA

1.15 (1.05 to 1.25)

Asian:

Hotta

2,451 (927/1,524)

0.26/0.21

0.593

499/947

367/504

61/73

1.32 (1.15 to 1.51)

1.32 (1.16 to 1.51)


Total N (rs1121980)

5,100 (1,764/3,336)

Pooled ORs

1.46 (1.17 to 1.83)

1.34 (1.10 to 1.62)


Total Subjects (duplicated subjects were excluded)

112,327 (42,616/69,711)


a: 11, 12, and 22 denote TT, TA, and AA for rs9939609; TT, TC, and CC for rs1421085; CC, CA, and AA for rs8050136; TT, TG, and GG for rs17817449; and GG, GA, and AA for rs1121980.

Peng et al. BMC Medicine 2011 9:71   doi:10.1186/1741-7015-9-71

Open Data