Table 1

Clinical characteristics of the included studies

Study

Publication year

Country

Ethnicity

Case

Control


Mean age (SD)

(years)

Mean BMI (SD)

(kg/m2)

Mean age (SD)

(years)

Mean BMI (SD) (kg/m2)


Frayling_a [4]a

2007

UK

Caucasian

NAg

NA

28.4 (4.7)

22.7

Frayling_b

2007

UK

Caucasian

NA

NA

31.0

24.4

Frayling_c

2007

UK

Caucasian

NA

NA

40.6 (6.1)

25.6

Frayling_d

2007

UK

Caucasian

NA

NA

56.7 (4.5)

26.4

Frayling_e

2007

UK

Caucasian

60.1 (8.8)

32.8

59.7 (9.0)

26.1

Frayling_f

2007

UK

Caucasian

NA

NA

68.8 (5.5)

27.2

Frayling_g

2007

UK

Caucasian

NA

NA

74.3 (6.9)

27.2

Hinney [43]b

2007

Germany

Caucasian

14.4 (3.7)

33.4 (6.8)

26.1 (5.8)

18.3 (1.1)

Dina_a [6]

2007

France

Caucasian

44 (12)

47 (7.6)

51 (10)

22.8 (2)

Dina_b

2007

France

Caucasian

10.6 (3.5)

NA

49 (5.5)

22.3 (2.3)

Dina_c

2007

France

Caucasian

11.8 (3.1)

29.8 (5.8)

22.0 (3.7)

21.1 (2.0)

Dina_d

2007

Switzerland

Caucasian

NA

46.7 (5.5)

NA

NA

Dina_e

2007

Germany

Caucasian

11.6 (2.7)

NA

11.7 (1.7)

NA

Song_H [31]c

2007

USA

Hispanic

NA

NA

61.1 (6.71)

30.9 (7.1)

Song_AP

2007

USA

Asian

NA

NA

60.2 (6.77)

29.0 (5.78)

Song_B

2007

USA

African

NA

NA

63.8 (7.58)

24.7 (4.49)

Villalobos [40]

2008

Mexico

South American

43.9 (13.1)

39.4 (8.6)

NA

NA

Chang [35]

2008

China-Taiwan

Asian

37.0 (0.56)

38.9 (8.2)

61.1 (0.33)

24.0 (2.9)

Hotta [37]

2008

Japan

Asian

49.1 (14.2)

34.5 (5.4)

48.2 (16.5)

21.7 (2.1)

Li [15]

2008

China

Asian

NA

NA

58.6 (6.0)

24.2

Peeters [41]

2008

Belgium

Caucasian

NA

38.3 (0.3)

NA

NA

Jacobsson_2008 [42]

2008

Sweden

Caucasian

12.6 (3.3)

35.4 (6.6)

17.1 (0.8)

21.1 (2.6)

Muler [44]d

2008

Germany

Caucasian

10.7 (3.1)

28.9 (5.2)

24.6 (2.6)

21.8 (1.1)

Andreasen_a [45]

2008

Denmark

Caucasian

NA

NA

46.2 (7.9)

26.3 (4.6)

Andreasen_be

2008

Denmark

Caucasian

NA

NA

60.0 (6.8)

28.6 (4.9)

Andreasen_c

2008

Denmark

Caucasian

NA

NA

58.5 (8.1)

26.5 (4.2)

Grant_C [51]

2008

USA

Caucasian

2-18

BMI ≥95th percentile

2-18

BMI<95th percentile

Grant_AA

2008

USA

African

2-18

BMI ≥95th percentile

2-18

BMI<95th percentile

Price [33]

2008

USA

Caucasian

41.1 (9.4)

49.1 (8.8)

42.6 (8.8)

20.8 (1.8)

Legry [36]

2008

France

Caucasian

52.9 (8.2)

33.8 (3.5)

48.9 (8.5)

22.5 (1.8)

Gonzalez [39]

2009

Spain

Hispanic

58.0 (11.0)

33.0 (3.3)

54.0 (11.0)

25.8 (2.6)

Zabena [38]

2009

Spain

Hispanic

44.8 (12.5)

45.5 (7.4)

45.5 (7.3)

24.3 (2.4)

Tabara [32]f

2009

Japan

Asian

NA

NA

61.0 (14.0)

23.4 (3.2)

Attaoua [49]

2009

France

Caucasian

39.1 (11.4)

39.4 (3.8)

39.6 (11.6)

23.8 (2.6)

Meyre_FC [50]

2009

France

Caucasian

11.5 (3.1)

29.0 (9.8)

21.0 (4.5)

20.74 (2.2)

Meyre_FA

2009

France

Caucasian

41.1 (10.9)

49.4 (7.8)

49.1 (5.5)

22.3 (2.3)

Meyre_SA

2009

Switzerland

Caucasian

42.4 (11.5)

43.7 (7.2)

NA

NA

Meyre_GC

2009

Germany

Caucasian

11.8 (2.9)

29.7 (9.2)

11.8 (2.9)

18.15 (8.1)

Thorleifsson [52]

2009

Mixed

Mixed

NA

NA

NA

NA

Willer [34]

2009

Mixed

Mixed

NA

NA

NA

NA

Renstrom [53]

2009

Sweden

Caucasian

52.6 (9.5)h

>30

52.6 (9.5) h

18.5-24.9

Jacobsson_2009 [47]

2009

Sweden

Caucasian

50.0 (0)

32.1 (1.9)

50.0 (0)

24.8 (1.8)

Karasawa [48]f

2010

Japan

Asian

NA

NA

63.0 (1.2)

23.5 (3.2)

Liu [46]

2010

China

Asian

NA

NA

58.0 (9.0)

24.5 (3.2)

Cheung [30]

2010

China

Asian

46.3 (11.9)

32.2 (4.9)

45.0 (12.5)

21.2 (1.2)


a: The article by Frayling et al. contains seven studies, namely Frayling _a (ALSPAC), Frayling _b (NFBC1966), Frayling _c (Oxford Biobank), Frayling _d (Caerphilly), Frayling _e (EPIC-Norfolk), Frayling _f (BWHHS), and Frayling _g (InCHIANTI). Please refer to the original article [4] for details.

b: Early-onset, extremely obese cases (mean BMI Z score 4.63 ± 2.27) and healthy, underweight controls (mean BMI Z score -1.38 ± 0.35; BMI <15thage percentile).

c: The age and BMI values are reported as the mean value of all case and control subjects.

d: Obese cases are reported as the 99.5th percentile of the median age and gender-specific BMI. Lean controls are reported as the 51.0st percentile of the median age and gender-specific BMI.

e: The article by Andreasen et al. contains three studies, including Andreasen_a (Population-based, Inter99 study sample), Andreasen_b

(ADDITION study cohort), and Andreasen_c (SDC control group). For details, please refer to the original article [45].

f: In Japan, obesity is defined as a condition in which the individuals had a BMI ≥25 kg/m2 according to the guidelines of the Japanese Society for the Study of obesity [68].

g: Not available.

h: The mean age of all subjects (non-diabetic individuals).

Peng et al. BMC Medicine 2011 9:71   doi:10.1186/1741-7015-9-71

Open Data