Survival rates, body weights and tumor volumes in mammary carcinomas of mice treated with 0, 10 and 20 mg/kg/day α-mangostin. α-Mangostin was administered via implanted mini-osmotic pumps. Each group consisted of ten mice. (A) Survival rates (%) were significantly greater in the 20 mg/kg/day group than the control group (*P < 0.05). (B) Body weights of mice treated with 10 and 20 mg/kg/day α-mangostin were similar to those in the control group with the exception of the 20 mg/kg/day mice at week one. (C) Increases in tumor volume in the 20 mg/kg/day group were significantly lower in weeks one to five compared to the control values (*P < 0.05; **P < 0.01). In the 10 mg/kg/day/day group, significant suppression of the tumor volume was observed in weeks one and two, with a decrease in growth suppression noted thereafter. Data are presented as mean ± SD.
Shibata et al. BMC Medicine 2011 9:69 doi:10.1186/1741-7015-9-69