Table 1 |
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Positron emission tomography techniques |
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|
Technique |
Target |
Use |
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18F-DOPA PET |
Aromatic amino acid decarboxylase (AADC) |
Provides measures of AADC activity and allows an indirect measure of DA storage within the DA terminals. |
|
11C-raclopride PET |
Post-synaptic DA D2 receptors |
Is a subject to competitive displacement by endogenous DA. Acute administration of substances such as amphetamine, methylphenidate, or L-DOPA, which are known to increase the levels of extracellular DA result in a reduction of 11C-raclopride binding. |
|
H215O PET |
Regional cerebral blood flow (rCBF) |
Brain activation and regional cerebral metabolism. |
|
76Br-FE-CBT PET |
Dopamine transporter (DAT) |
Marker of presynaptic DA terminals integrity and DAT availability |
|
123I-IPT SPECT |
DAT |
Marker of presynaptic DA terminals integrity and DAT availability |
|
123I-FP-CIT SPECT |
DAT |
Marker of presynaptic DA terminals integrity and DAT availability |
|
11C-PK11195 PET |
Translocator protein (TSPO) |
Is an 18 kDa protein of the outer mitochondrial membrane that is upregulated with activation of microglia |
|
11C-DASB PET |
5-HT transporter (SERT) |
Marker of presynaptic 5-HT terminals integrity and SERT availability |
|
11C-dihydrotetrabenazine (DTBZ) PET |
Vesicular monoamine transporter (VMAT2) |
Marker of presynaptic monoaminergic terminals integrity |
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Politis BMC Medicine 2011 9:50 doi:10.1186/1741-7015-9-50 |
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