Table 1 |
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|
Type of prescription according to GI risk |
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|
Type of drug |
Low GI risk N (%) |
Moderate GI risk N (%) |
High GI risk N (%) |
P-value** |
|
N = 1283 |
N = 5511 |
N = 10311 |
||
|
|
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|
SYSADOA |
55 (4.3) |
120 (2.2) |
80 (0.8) |
<0.0001 |
|
Paracetamol |
130 (10.1) |
535 (9.7) |
841 (8.2) |
0.001 |
|
Opioids |
12 (0.9) |
55 (1.0) |
59 (0.6) |
0.008 |
|
Combinations of any of the 3* |
80 (6.2) |
424 (7.7) |
1103 (10.3) |
<0.0001 |
|
NsNSAIDs |
615 (47.9) |
2,567 (46.6) |
4,734 (45.9) |
0.337 |
|
nsNSAID+ GP*** |
344/615 (55.9) |
2,093/2,567 (81.5) |
4,367/4,734 (92.2) |
<0.0001 |
|
|
||||
|
Cox-2 NSAID |
294 (22.9) |
1,636 (29.7) |
3,669 (35.6) |
<0.0001 |
|
Cox-2 + GP*** |
96/294 (32.7) |
880/1,636 (53.8) |
2.800/3,669 (76.3) |
<0.0001 |
|
|
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|
CV HX = cardiovascular history; GP = gastroprotectant (>91% proton pump inhibitors). * Sysadoa, paracetamol, opioids; ** P-values denotes differences among groups overall; *** nsNSAIDS + GP data express the number of patients and % of patients with nsNSAIDs prescription that also take a gastroprotective agent. Also, COX-2 + GP data express the number of patients and % of patients with COX-2 selective inhibitors prescriptions that also take a gastroprotective agent. |
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|
Lanas et al. BMC Medicine 2011 9:38 doi:10.1186/1741-7015-9-38 |
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