Table 5

Numeric codes describing the strength of evidence for an association of a gene with a disease.

Code

Kind of evidence


6

Known association of the gene with the disease.

5

Gene is known to interact with an intermediate, and the intermediate has a known association with the disease.

4

Known association of the gene with a function central to disease pathogenesis (for example, insulin secretion for diabetes).

3

Gene is known to interact with an intermediate, and the intermediate has a known association with a function central to disease pathogenesis.

2

Known association of a region containing the gene with the disease.

1

Gene disruption is known to have a general mutagenic effect.

0

No evidence.


Ross BMC Medicine 2011 9:12   doi:10.1186/1741-7015-9-12

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