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Advances in understanding ischemic acute kidney injury

Raj Munshi1, Christine Hsu1 and Jonathan Himmelfarb2*

Author Affiliations

1 Department of Pediatrics, Division of Nephrology, University of Washington and Seattle Children's Hospital, Seattle, WA, USA

2 Kidney Research Institute, Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA, USA

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BMC Medicine 2011, 9:11  doi:10.1186/1741-7015-9-11

Published: 2 February 2011

Abstract

Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.