Table 4

Correlation between protein expression levels of telomerase reverse transcriptase (TERT) and MNS16A genotypes by immunohistochemistry

Tissues

Genotypesa

Expression levels,bn

Pc



Negative

Low

High

NPC vs.

non-NPC

LL vs.

SL + SS


NPCd tissues

4. 78 × 10-7

0. 035

LL

5

11

21

SL

2

2

0

SS

0

0

0

Non-cancere

NAf

LL

11

0

0

SL

1

0

0

SS

1

0

0


aL allele, 302 or 333 bp; S allele, 243 or 272 bp.

bExpression levels were classified into three groups (negative, low and high expression) based on the scores of the immunohistochemistry signals.

cThe difference of the TERT protein level between the genotypes was assessed by a trend χ2 test. The difference of the protein level between the tumors and non-cancerous nasopharyngeal tissues was assessed by a Wilcoxon signed-ranks test.

dNasopharyngeal cancer

eNon-cancerous nasopharyngeal tissues

fNot available.

Zhang et al. BMC Medicine 2011 9:106   doi:10.1186/1741-7015-9-106

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