Table 6

Motor impairment - muscle function

Time-point

Study

Measure used

Augmented therapy

Standard therapy

Mean difference

Number subjects

Mean (SD)

Number subjects

Mean (SD)

Effect size

[95% CI]


Outcome

4 weeks after start therapy

GAPS

Motricity arm + leg

33

119.0 (46.0)

34

111.0 (45.0)

8.0

[-13.8,29.8]

20 weeks after start therapy

Kwakkel

Motricity leg

26

68.2 (25.8)

34

45.2 (24.8)

23.0

[10.0,35.9]

20 weeks after start therapy

Kwakkel

Motricity arm

29

53.1 (32.0)

34

28.9 (28.5)

24.2

[9.2,33.1]

6 weeks after start therapy

Donaldson

Hand grip force

10

71.9 (49.5)

8

64.8 (39.3)

7.1

[-34.0,48.1]

5 weeks after start therapy

Lincoln

Hand grip strength

87

0 (25.19)

90

11.0 (36.3)

-11.0

[-20.2,-1.8]

Subtotal - hand grip force/strength

97

98

-10.1

[-19.1,-1.2]

6 weeks after start therapy

Donaldson

Pinch grip force

10

31.5 (23.1)

8

24.5 (19.7)

7.0

[-12.8,26.8]

6 weeks after start therapy

Donaldson

Elbow extend force

10

64.5 (44.6)

8

68.6 (39.6)

-4.1

[-43.1,34.8]

6 weeks after start therapy

Donaldson

Elbow flexion force

10

76.1 (58.7)

8

75.0 (38.7)

1.1

[-44.1,46.3]

6 weeks after start therapy

Cooke

Knee extend torque

26

45.3 (33.2)

25

27.8 (26.3)

17.5a

[1.1, 33.9]

6 weeks after start therapy

Cooke

Knee flexion torque

26

34.0 (23.1)

25

19.0 (17.8)

15.0a

[3.7, 26.3]

Follow-up 1

3 months after start therapy

GAPS

Motricity arm + leg

32

130.0 (44.0)

33

120.0 (42.0)

10.0

[-10.9,30.9]

26 weeks after start therapy

Kwakkel

Motricity leg

26

68.2 (25.3)

34

27.2 (26.8)

41.0

[27.7,54.3]

26 weeks after start therapy

Kwakkel

Motricity arm

29

48.6 (31.1)

34

31.1 (30.1)

17.5

[2.3,32.7]

3 months after stroke

Rodgers

Motricity arm

54

85.0 (20.0)

51

78.0 (36.3)

7.0

[-4.3,18.3]

Subtotal - Motricity arm

83

85

10.7

[1.7,19.8]

18 weeks after start therapy

Cooke

Knee extend torque

19

56.4 (36.3)

18

37.9 (27.8)

18.5a

[-2.3, 39.3]

18 weeks after start therapy

Cooke

Knee flexion torque

19

41.7 (28.8)

18

25.2 (22.9)

16.5a

[-0.2, 33.2]

3 months after start therapy

Lincoln

Hand grip strength

84

9.0 (28.2)

84

19.0 (43.0)

-10.0

[-19.5,1.8]

Follow-up 2

6 months after start therapy

Lincoln

Hand grip strength

81

23.0 (40.7)

81

25.0 (45.2)

-2.0

[-15.3,11.3]

6 months after stroke

Rodgers

Motricity arm

48

83.0 (28.2)

48

77.0 (25.9)

6.0

[-4.8,16.8]

6 months after start therapy

GAPS

Motricity arm + leg

30

124.0 (42.0)

34

121.0 (51.0)

3.0

[-19.8,25.8]


a = fixed effect model used; b = random effect model used; FU = Follow-up; * = < 0.05

Cooke et al. BMC Medicine 2010 8:60   doi:10.1186/1741-7015-8-60

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