Table 5

Joint effects of the IL1-CCC haplotype and other risk factors on CAD.

Trait

Factor

P_value

Odds ratio

95 CI*


CAD

IL1 CCC

0.047

1.22

1.00

1.47


Sex (baseline = female)

<0.001

4.86

4.00

5.91


Ever smoked

<0.001

2.01

1.62

2.50


Hypertension

<0.001

3.16

2.55

3.92


Overall test (4df)

P < 0.0001


CAD before 50 years

IL1 CCC

0.002

1.53

1.17

2.01


Sex (baseline = female)

<0.001

6.44

4.78

8.67


Ever smoked

<0.001

3.03

2.16

4.26


Hypertension

<0.001

3.57

2.56

5.00


Overall test (4df)

P < 0.0001


* 95% confidence interval (CI)

CAD, coronary artery disease.

Brown et al. BMC Medicine 2010 8:5   doi:10.1186/1741-7015-8-5

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