Table 2

Clinical characteristics of the study sample.

Unaffected

Affected


Risk factor

N (%)

N (%)

Univariate

P-value *

Multivariable

OR†


Total sample

1545 (100)

1154 (100)

-

-


Male sex

630 (40.8)

873 (75.7)

<0.0001

4.71 (3.65, 6.08)


Diabetes mellitus

62 (4.0)

117 (10.1)

<0.0001

1.63 (1.00, 2.66)


Hypertension

391 (25.3)

522 (45.2)

<0.0001

1.99 (1.52, 2.60)


Hypercholesterolaemia

454 (29.4)

945 (81.9)

<0.0001

10.70 (8.11, 14.11)


Ever smoked

856 (55.4)

849 (73.6)

<0.0001

1.72 (1.32, 2.25)


BMI

Mean (SD)

27.16 (4.62)

Mean (SD)

27.74 (4.05)

0.0002

1.00 (0.97, 1.04)


* Univariate conditional logistic regression for binary factors and linear regression clustered by family for body mass index (BMI)

† Odds ratio (OR) and 95% confidence intervals from multivariable conditional logistic regression analysis including all six factors

SD: standard deviation

Brown et al. BMC Medicine 2010 8:5   doi:10.1186/1741-7015-8-5

Open Data