Table 2

Antiemetic agents and supposed dosage in hyperemesis gravidarum, adapted from references [13,62,98]

Food and Drug Admnistration category

Medication

Administration

Suggested dosage


A

Pyridoxine (vitamin B6)

Oral

20 mg 3 × per day (max. dose: 200 mg per day)


Doxylamine

Oral

25 mg at night and 12.5 mg in the morning accompanied by 10 mg of pyridoxine (maximum dose: 80 mg per day)


B

Ondansetron

Oral/intravenously (IV)

4-8 mg 2-3× per day/2-4 mg every 6-8 h or 8 mg every 12 h IV


Metoclopramide

Oral

5-10 mg 3-4 × per day


Meclizine

Oral/rectal

25-100 mg 2-4 × per day/1 × per day


Diphenhydramine

Oral/IV

25-50 mg every 6-8 h


Dimenhydrinate

Oral/IV/rectal

50 mg 3-4× per day/62 mg 2× per day/1-3× per day


C

Promethazine

Oral/IV

12.5-25 mg up to 6 × per day


Prochlorperazine

Rectal

25 mg per day or 2× per day


Prednisolone

Oral

40-60 mg per day reducing by half every 3 days


-

Ginger

Oral (biscuits, confectionary, crystals, powder, tablets, capsules, fresh ginger)

Up to 1 g per day in divided doses


Jueckstock et al. BMC Medicine 2010 8:46   doi:10.1186/1741-7015-8-46

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