Table 4 |
||||
|
Univariate and multivariate (backward conditional selection) Cox regression analysis of metastasis-free survival (MFS) in breast cancer patients considering clinicopathological characteristics, tumour microvessel density and hypoxia inducible factor 1α (HIF-1α)TAG mRNA levels |
||||
|
Characteristics |
Univariate analysis of MFS, Exp B (95% CI) |
P value |
Multivariate analysis of MFS, Exp B (95% CI) |
P value |
|
|
||||
|
Age, years: |
||||
|
< 50 |
1 |
0.561 |
||
|
≥ 50 |
1.32 (0.52 to 3.37) |
|||
|
Positive lymph node: |
||||
|
0 |
1 |
0.003 |
1 |
0.005 |
|
1 to 3 |
8.00 (2.56 to 24.81) |
5.56 (1.75 to 17.63) |
||
|
4 to 9 |
7.50 (1.70 to 30.00) |
6.68 (1.48 to 30.14) |
||
|
> 10 |
1.20 (0.14 to 10.00) |
0.48 (0.05 to 4.25) |
||
|
Pathological tumour size, mm: |
||||
|
< 10 |
1 |
0.39 |
||
|
10 to 20 |
1.10 (0.10 to 8.70) |
|||
|
21 to 49 |
2.40 (0.30 to 18.90) |
|||
|
> 50 |
2.70 (0.20 to 42.90) |
|||
|
Tumour grade: |
||||
|
1/2 vs |
1 |
0.24 |
||
|
3 |
1.70 (0.70 to 4.40) |
|||
|
Peritumoural vascular invasion: |
||||
|
Absent |
1 |
0.104 |
||
|
Present |
3.40 (0.80 to 14.80) |
|||
|
OR status: |
||||
|
Positive |
||||
|
Negative |
0.33 (0.13 to 0.85) |
0.021 |
||
|
PgR status: |
||||
|
Positive |
||||
|
Negative |
0.20 (0.07 to 0.60) |
0.005 |
0.23 (0.07 to 0.72) |
0.012 |
|
Tumour microvessel density |
1.02 (0.07 to 0.60) |
0.22 |
||
|
HIF-1αTAG mRNA levels |
1.03 (1.00 to 1.05) |
0.01 |
||
|
|
||||
|
OR = oestrogen receptor; PgR = progesterone receptor, Exp B = exponential of beta |
||||
|
Dales et al. BMC Medicine 2010 8:44 doi:10.1186/1741-7015-8-44 |
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