Table 2

Summary of studies using GDF-15 for risk stratification of AMI

Study Pop

N

Endpoints

Thresholds

Odds ratio or Hazard Ratio

Ref


GUSTOIV (NSTEACS)

2,081 + 429

Death (one year)

Tertiles < 1,200 ng/L, 1,200 to 1,800 ng/L > 1,800 ng/L

1.5%, 5%, 14.1%

[46]


FRISC-II (invasive vs conservative)

2,079

Death or MI (2 yrs)

Invasive at > 1,800 ng/L Invasive 1,200 to 1,800 ng/L Invasive < 1,200 or Trop -ve

HR 0.49 (risk reduction) HR 0.68 No benefit

[47]


ASSENT-2/plus (STEMI)

741

Death (1 yr)

Tertiles < 1,200, 1,200 to 1,800, > 1,800

2.1%, 5.0%, 14%

[48]


AMI

1,142

Death or HF (1.5 yr)

<1,470 ng/L, >1,470 ng/L

HR 1.77

[49]


Chan and Ng BMC Medicine 2010 8:34   doi:10.1186/1741-7015-8-34

Open Data