Table 1

Summary of studies using BNP or NTproBNP for ris stratification of AMI

Study Pop

N

Endpoints

Thresholds

Odds ratio or Hazard Ratio

Ref


ACS-TIMI16

2,525

Death (30 day, 10 months) HF(10 months) MI (10 months)

Quartiles BNP > 80 pg/ml

1, 3.8, 4.0, 5.8 Approximately 2.7 Approximately 2

[28]


AMI

70

Death (18 months)

Median (>59 pg/ml)

Approximately 2.5

[29]


AMI-CONSENSUS

131

Death (one year)

75th centile BNP 33.3 pmol/L

Approximately 1.36

[30]


ACS

609

Death

Median

2.4

[37]


NSTEACS

1,483

Death (in hosp) (180 days)

BNP > 586 pg/ml

(1.7) (1.67)

[38]


FRISC-II

2,019

Death

Top Tertile

4.1(invasive) vs 3.5(non-invasive)

[36]


TACTICS-TIMI18

1,676

Death (six months) HF (30 days)

BNP > 80 pg/ml

OR 3.3 OR 3.9

[35]


ACS

1,033

Death (30 day) (six months)

Quartiles

(2.24) (1.84)

[34]


AMI

473

Death

Median

OR 3.82

[39]


Chan and Ng BMC Medicine 2010 8:34   doi:10.1186/1741-7015-8-34

Open Data