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Open AccessHighly AccessResearch article

A compact VEGF signature associated with distant metastases and poor outcomes

Zhiyuan Hu1,2 email, Cheng Fan1 email, Chad Livasy1,3 email, Xiaping He1,2 email, Daniel S Oh1,2 email, Matthew G Ewend1,4 email, Lisa A Carey1,4 email, Subbaya Subramanian5 email, Robert West5 email, Francis Ikpatt6 email, Olufunmilayo I Olopade6 email, Matt van de Rijn5 email and Charles M Perou1,2,3 email

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA

Section of Hematology/Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, South Maryland Avenue, Chicago, IL 60637-1463, USA

author email corresponding author email

BMC Medicine 2009, 7:9doi:10.1186/1741-7015-7-9

Published: 16 March 2009

Additional files

Additional file 1:

Supplementary table. Summary of GEO submission of 202 microarrays used in this paper and clinical data of the patients in this study.

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Additional file 2:

Figure S1. The complete cluster diagram of all 146 patients using the 1195 gene. MetScore-associated gene list.

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Additional file 3:

Figure S2. Univariate Kaplan-Meier survival plots for patients stratified using the VEGF profile based upon rank order expression on the A-B) UNC training data set, C-D) NKI test data set, E-F) Bhattacharjee et al [29] lung carcinoma data set, and G-H) Nutt et al [30] glioblastoma data set.

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