Table 2

Gene list predicting sensitivity (S) or resistance (R) to PG-11047 treatment.

Gene symbol

P-value

Predict

Chromosome location

Gene name

Function

References


WASL

2.5E-05

R

chr7q31.3

Wiskott-Aldrich syndrome-like

Key regulator of cell migration and actin polymerization by interaction with Ap2/3 complex

[32,47]


GCLM

4.7E-05

S

chr1p22.1

Glutamate-cysteine ligase, modifier subunit

Regulatory subunit of glutamate-cystein ligase, a rate-limiting enzyme catalyzing the first step of GSK biosynthesis from cysteine

[39]


CST3

6.3E-05

R

chr20p11.21

Cystatin C (amyloid angiopathy and cerebral haemorrhage)

Potent inhibitor of lysosomal proteinases. TGFβ receptor antagonist, inhibit epithelial-mesenchymal transition and morphological transformation

[30]


LAMA3

6.7E-05

S

chr18q11.2

Laminin, alpha 3

Component of laminin 5, the major extracellular metrix protein produced in the basement membrane of the mammary epithelial cells. Induces motility, invasion and epithelial-mesenchymal transition

[35,48]


SSRP1

1.2E-04

S

chr11q12

Structure specific recognition protein 1

Histone chaperone. Forms a heterodimer with Spt16 and is a component of the chromatin transcript regulation factor, FACT

[40,42]


ACYP1

1.2E-04

S

chr14q24.3

Acylphosphatase 1, erythrocyte (common) type

Catalyze the hydroolysis of acylphosphates

[49]


CYLD

2.9E-04

S

chr16q12.1

Cylindromatosis (turban tumour syndrome)

A deubiquinating enzyme that negatively regulate the activity of NFkB and JNK. Regulate mitotic entry

[43,45]


PRPF18

3.0E-04

S

chr10p13

PRP18 pre-mRNA processing factor 18 homolog (Saccharomyces cerevisiae)

Participate in pre-mRNA splicing, prepare mRNA for translation

[41]


AMFR

3.1E-04

S

chr16q21

Autocrine motility factor receptor

Receptor for AMF, a tumour motility-stimulating protein secreted by tumour cells. Stimulation of AMFR by AMF alters cellular adhesion, proliferation, motility and apoptosis

[33,36]


DEAF1

7.9E-04

R

chr11p15.5

Deformed epidermal autoregulatory factor 1 (Drosophila)

A sequence-specific DNA-binding protein required for development. May be a general regulator of gene transcription/expression. DEAF1 (also called 'suppressin') appear to be mutated in tumours and cell lines

[50,51]


PPP1R2

1.5E-03

S

chr3q29

Protein phosphatase 1, regulatory (inhibitor) subunit 2

Inhibitor of protein phosphatase 1. Phosphorylation of PPP1R2 by glycogen synthase kinase-3 (GSK3) activates the enzyme. PPP1R2 (INH2) regulates PP1 complexed with NEK2 to induce centrosome separation

[44]


LOH11CR2A

1.7E-03

S

chr11q23

Loss of heterozygosity, 11, chromosomal region 2, gene A

Frequent loss of heterozygosity at 11q23 region found in many tumour types

[46]


ACSL3

1.8E-03

R

chr2q34-q35

Acyl-CoA synthetase long-chain family member 3

Essential for fatty acid metabolism, providing activated intermediates for complex lipid synthesis, protein modification, and beta oxidation

[52]


Kuo et al. BMC Medicine 2009 7:77   doi:10.1186/1741-7015-7-77

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