Table 1

Significant pathways from top 250 predictor genes associated with response to PG-11047 treatment using Ingenuity Pathway analysis.

Pathway Name

P-Value

Ratio

Component genes in the pathway


Interferon Signaling

0.001

[4/29]

IRF1, IRF9, TAP1, IFNGR1


Ephrin Receptor Signaling

0.011

[8/193]

CXCR4, ABI1, RAP1A, MAPK1, WASL,

MAP4K4, GNAI3, PAK1


Role of BRCA1 in DNA Damage

Response

0.013

[4/52]

RPA1, RFC3, MSH2, E2F3


Nicotinate and Nicotinamide

Metabolism

0.019

[5/129]

NNMT, ENPP2, MAPK1, ENPP1, PAK1


Fcy Receptor -mediatedPhagocytosis in Macrophages andMonocytes

0.028

[5/104]

RPS6KB1, LYN, MAPK1, VAMP3, PAK1


Riboflavin Metabolism

0.032

[2/49]

ENPP2, ENPP1


Endoplasmic Reticulum Stress

Pathway

0.041

[2/18]

XBP1, TAOK3


Pantothenateand CoA Biosynthesis

0.046

[2/63]

ENPP2, ENPP1


CXCR4 Signaling

0.052

[6/164]

CXCR4, RHOB, LYN, MAPK1, GNAI3, PAK1


PI3K/AKT Signaling

0.055

[5/135]

RPS6KB1, SFN, MAPK1, YWHAH, PPP2R5A


Integrin Signaling

0.056

[7/198]

RHOB, RAP1A, MAPK1, TSPAN6, WASL, ARF4, PAK1


Ratio indicates the number of genes in the top 250 predictors that belong to the pathway indicated over the number of genes known of the pathway. Genes in bold were associated with resistance when transcribed at high levels. Genes in normal fonts were associated with sensitivity when transcribed at high levels.

Kuo et al. BMC Medicine 2009 7:77   doi:10.1186/1741-7015-7-77

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