Research article
STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
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* Corresponding author: Nikolai N Khodarev n-khodarev@uchicago.edu
- † Equal contributors
1 Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA
2 Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
BMC Medicine 2009, 7:68 doi:10.1186/1741-7015-7-68
Published: 5 November 2009Additional files
Additional file 1:
Table S1 - Genes differentially expressed between untreated SCC61 Signal Transducer and Activator of Transcription 1 (STAT1) wild-type (WT) and knockdown (KD) tumours. Probe Set ID = Affymetrix probe set ID; GG = glycolysis/gluconeogenesis; OP = oxidative phosphorylation; CC = citrate cycle; expression values for duplicated SCC61 KD/control (C) and WT/C samples are log2-transformed signal intensities normalized to the mean signal intensity across each gene.
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Additional file 2:
Table S2 - Proteins differentially expressed between untreated SCC61 Signal Transducer and Activator of Transcription 1 (STAT1) wild-type (WT) and knockdown (KD) tumours. UniProt ID = Universal Protein Resource ID; GG = glycolysis/gluconeogenesis; OP = oxidative phosphorylation; CC = citrate cycle; expression values for duplicated SCC61 KD/C and WT/control (C) samples are log2-transformed total ion currents (TIC) normalized to the mean TIC across each protein.
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Additional file 3:
Table S3 - All differentially expressed genes and proteins associated with energy metabolism from pair-wise comparisons of Signal Transducer and Activator of Transcription 1 (STAT1) wild-type and knockdown tumours for untreated and irradiated conditions. GG = glycolysis/gluconeogenesis; OP = oxidative phosphorylation; CC = citrate cycle; Probe Set/UniProt ID = Affymetrix probe set/Universal Protein Resource ID; expression values are raw signal intensities for genes or total ion currents for proteins.
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Additional file 4:
Table S4 - Differential expression of energy metabolic genes and proteins in response to ionizing radiation (IR) of Signal Transducer and Activator of Transcription 1 (STAT1) wild-type (WT) and knockdown (KD) tumours. GG = glycolysis/gluconeogenesis; OP = oxidative phosphorylation; CC = citrate cycle; (WT/IR)/(WT/C) = response of STAT1 WT tumour to IR; (KD/IR)/(KD/C) = response of STAT1 KD tumour to IR; WT/KD = ratio of WT IR response to KD IR response.
Format: XLS Size: 47KB Download file
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