Table 4 |
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Odds ratios for baseline and time-varying predictors of adherence ≥ 90%. |
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|
Baseline characteristics |
Univariate model OR (95% CI) P* |
Multivariate model† AOR (95% CI) P* |
|
|
|
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|
Dosing schedule (prophylaxis group) |
Three times a week |
1 |
1 |
|
Daily |
0.88 (0.66, 1.17) 0.38 |
0.85 (0.64, 1.11) 0.23 |
|
|
|
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|
Study site |
RCCH |
1 |
1 |
|
TCH |
1.25 (0.95, 1.67) 0.11 |
1.12 (0.82, 1.54) 0.46 |
|
|
|
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|
Gender |
Male |
1 |
1 |
|
Female |
1.17 (0.87, 1.57) 0.30 |
1.11 (0.82, 1.50) 0.51 |
|
|
|
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|
Number of individuals in house |
≤ 5 |
1 |
1 |
|
> 5 |
0.77 (0.57 1.02) 0.07 |
0.71 (0.54, 0.95) 0.02 |
|
|
|
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|
Brick house |
No |
1 |
- |
|
Yes |
0.98 (0.73, 1.30) 0.87 |
||
|
|
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|
Tap water in house |
No |
1 |
- |
|
Yes |
1.07 (0.80, 1.43) 0.64 |
||
|
|
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|
Flush toilet in house |
No |
1 |
- |
|
Yes |
1.08 (0.82, 1.44) 0.57 |
||
|
|
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|
Electricity in house |
No |
1 |
- |
|
Yes |
0.93 (0.61, 1.41) 0.74 |
||
|
|
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|
Time-varying characteristics |
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|
|
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|
Age at visit |
< 1 year |
1 |
1 |
|
1-4 years |
0.77 (0.6, 0.98) 0.03 |
1.47 (0.91, 2.37) 0.11 |
|
|
> 4 years |
1.40 (1.09, 1.80) 0.008 |
1.96 (1.16, 3.32) 0.012 |
|
|
|
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|
Time on study at visit |
< 1 year |
1 |
1 |
|
≥ 1 year |
0.82 (0.67, 1.01) 0.06 |
0.83 (0.66, 1.05) 0.12 |
|
|
|
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|
CDC clinical |
N or A |
1 |
1 |
|
stage at visit |
B |
1.11 (0.85, 1.46) 0.44 |
0.85 (0.54, 1.34) 0.48 |
|
C |
0.86 (0.65, 1.14) 0.30 |
0.71 (0.43, 1.16) 0.17 |
|
|
|
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|
CDC immune |
1 |
1 |
1 |
|
Stage at visit |
2 |
0.94 (0.73, 1.20) 0.62 |
0.96 (0.69, 1.34) 0.83 |
|
3 |
1.02 (0.79, 1.32) 0.86 |
1.00 (0.70, 1.44) 0.99 |
|
|
|
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|
Study drug at visit |
Placebo |
1 |
- |
|
Isoniazid |
1.02 (0.73, 1.43) 0.91 |
- |
|
|
|
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|
On HAART at visit |
No |
1 |
1 |
|
Yes |
1.14 (0.89, 1.45) 0.30 |
1.08 (0.82, 1.43) 0.56 |
|
|
|
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|
† Adjusted for group, site, sex, number of people in house, age at visit, concurrent HAART, CDC immune stage at visit, CDC clinical stage at visit, time on study at visit. Two patients excluded from multivariate model due to missing information on number of people in the house and CDC immune staging at follow up. OR = odds ratio; AOR = adjusted OR; CI = confidence interval; RCCH = Red Cross War Memorial Children's Hospital; TCH = Tygerberg Children's Hospital; CDC = Centers for Disease Control and Prevention; HAART = highly active antiretroviral therapy; * P values from Wald tests |
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|
le Roux et al. BMC Medicine 2009 7:67 doi:10.1186/1741-7015-7-67 |
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