Email updates

Keep up to date with the latest news and content from BMC Medicine and BioMed Central.

Journal App

google play app store
Open Access Highly Accessed Minireview

Human cellular restriction factors that target HIV-1 replication

Klaus Strebel1, Jeremy Luban2 and Kuan-Teh Jeang1*

Author Affiliations

1 Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA

2 Department of Microbiology and Medicine, University of Geneva, Geneva, Switzerland

For all author emails, please log on.

BMC Medicine 2009, 7:48  doi:10.1186/1741-7015-7-48

Published: 16 September 2009


Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.