Human cellular restriction factors that target HIV-1 replication

doi:10.1186/1741-7015-7-48

BMC Medicine
Volume 7

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Jeang KT

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Human cellular restriction factors that target HIV-1 replication

Klaus Strebel¹ , Jeremy Luban² and Kuan-Teh Jeang¹

¹Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA

²Department of Microbiology and Medicine, University of Geneva, Geneva, Switzerland

author email corresponding author email

BMC Medicine 2009, 7:48doi:10.1186/1741-7015-7-48


Published:	16 September 2009

Abstract

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.