Table 5

In-hospital outcomes for the three main bacterial pathogens, by study

Reference

Bacteria

Country

No. of CBM cases

In-hospital CFR

Total no. cases assessed for sequelae

HL (%)

VL (%)

CD (%)

BP (%)

MI (%)

SZ (%)

Any neuropsychological sequelae (%)


[38]

Spn

Cameroon

74

39%

45

16%

[37]

Spn

Cote d'Ivoire

330

60%

132

25%

[47]

Spn

Ghana

33

36%

[67]

Spn

Mali and Niger

115

67%

38

21%

[22]

Spn

The Gambia

134

48%

[57]

Spn

Madagascar

40

40%

[51]

Spn

Malawi

62

44%

32

25%

[44]

Spn

Gabon

42

29%

30

20%

[33]

Spn

Morocco

141

9%

128

27%

[15]

Spn

Tunisia

73

14%

61

7%

2%

5%

3%

34%

[41]

Spn

Egypt

106

27%

[14]

Spn

South Africa

79

30%

55

5%

38%

[54]

Spn

Kenya

92

36%

59

32%

[40]

Spn

Senegal

142

32%

96

28%

[54]

Hib

Kenya

77

17%

64

25%

[60]

Hib

Sudan

25

16%

[38]

Hib

Cameroon

53

25%

40

15%

[37]

Hib

Cote d'Ivoire

314

21%

248

6%

1%

2%

17%

[36]

Hib

The Gambia

77

25%

[67]

Hib

Mali and Niger

133

36%

85

28%

[40]

Hib

Senegal

216

18%

178

6%

3%

2%

27%

[22]

Hib

The Gambia

123

27%

[66]

Hib

Burkina Faso

92

22%

72

7%

18%

[57]

Hib

Madagascar

35

29%

25

44%

[51]

Hib

Malawi

44

41%

[44]

Hib

Gabon

36

31%

[59]

Hib

Algeria

57

4%

55

2%

2%

4%

[41]

Hib

Egypt

56

30%

[42]

Hib

South Africa

35

11%

31

26%

32%

32%a

[45]

Nm

Ethiopia

124

2%

121

3%

8%

[62]

Nm

Sudan

108

4%

104

3%

2%

5%

[64]

Nm

Cameroon

77

5%

73

1%b

1%

3%

[67]

Nm

Mali and Niger

161

13%

140

5%

[40]

Nm

Senegal

153

5%

146

10%

[41]

Nm

Egypt

267

6%

[34]

Nm

Morocco

118

1%

117

9%

3%

1%

2%

1%

21%

[50]

Nm

Tunisia

57

4%


This table presents the in-hospital sequelae and case fatality ratio (CFR) data available for 25 or more children diagnosed or surviving meningitis caused by 1 of the 3 main bacterial causes. Sequelae prevalences ranged from 16% to 38% for Spn meningitis, 4% to 44% for Hib meningitis and 3% to 21% for Nm meningitis.

aEstimated 'Any neuropsychological sequelae' based on single sequelae type with largest proportion; bparalysis.

BP = behavioural problem; CBM, confirmed bacterial meningitis; CD = cognitive delay; Hib = Haemophilus influenzae type b; HL = hearing loss; MI = motor impairment; Nm = Neisseria meningitidis; Spn = Streptococcus pneumoniae; SZ = seizures; VL = vision loss.

Ramakrishnan et al. BMC Medicine 2009 7:47   doi:10.1186/1741-7015-7-47

Open Data