Table 3

Characteristic of 139 patients with type 1 diabetes divided according to the median urine IgM level into low (<0.01 mg/mol) and high IgM (>0.01 mg/mol) groups.

Variable

Low IgM group

High IgM group

P value


At baseline:

Sex (male/female)

71 (49/22)

68 (30/38)

0.003

Age (years)

35(18-74)

37(20-80)

0.05

Duration of diabetes (yr)

15 (1-65)

24 (1-67)

0.001

HbA1c %

8.3 (4.5-13.4)

9 (5.5-13.2)

0.06, ns

Albuminuria (mg/mmol)

3.6(0.23-268)

21.3 (0.26-640)

<0.001

S. Creatinine ╬╝mol/l

78 (54-216)

86 (42-486)

0.009

GFR (ml/min/1.73 m2)

88 (27-141)

67(9-144)

<0.001

MAP mmhg

93 (80-120)

100 (78-133)

0.004

ACEI/ARBs, n/n (%)

3/2 (7.1%)

15/6 (31%)

<0.001

During follow-up:

Follow up time (years)

19 (2-22)

14 (1-22)

<0.001

MAP mmhg

97 (73-119)

103 (73-147)

0.038

HbA1c (%)

8.25 (4.5-13.9)

8 (4.5-13.4)

0.7, ns

Albuminuria (mg/mmol)

1.3 (0.1-676)

20.5 (0.1-1101)

<0.001

ACEI/ARBs, n/n (%)

12/14 (37%)

22/17 (59%)

0.008

CV-Mortality rate per patient-year

0.005838

0.029104

<0.001

Renal failure rate per patient-year

0.003451

0.022161

0.003


Abbreviations: ACEI: Angiotensin converting enzyme inhibitors; ARBs: Angiotensin II receptor antagonists; CV: cardiovascular; ESRD: End stage renal disease; GFR: glomerular filtration rate; HbA1c: glycosylated hemoglobin; MAP: Mean arterial blood pressure.

Tofik et al. BMC Medicine 2009 7:39   doi:10.1186/1741-7015-7-39

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