Table 1

Characteristic of 139 patients with type 1 diabetes divided according to initial degree of albuminuria into normo (45), micro (46), and macro (48).

Variable

Normal

Micro

Macro

P value


At baseline:

Sex (Male/Female)

44 (29/15)

46 (25/21)

49 (25/24)

0.3, ns

Age (years)

34 (20-72)

35 (18-80)

38 (21-79)

0.09, ns

Duration of diabetes

11 (1-54)

18 (1-65)

25 (1-67)

<0.001

S. creatinine (μmol/l)

74 (54-110)

80 (42-175)

103 (61-486)

<0.001

GFR (ml/min/1.73 m2)

91(45-141)

78 (28-144)

60(9-105)

<0.001

Urine IgM (mg/mmol·10-3)

6.7(1.7-31.8)

8.7(2.5-40)

11.5(2.8-363)

0.009

HbA1c %

7.6(4.5-13.4)

8.8(5.5-13.2)

9.1(6.2-12.7)

0.01

ACEI/ARBs, n/n (%)

0/0 (0%)

3/3 (13%)

15/5 (40.8%)

<0.001

MAP, mmhg

92(78-110)

96(80-127)

103(82-133)

<0.001

During follow-up:

Follow up time, years

19(2-22)

19(2-22)

9(1-22)

0.01

MAP, mmhg

93(73-127)

99(78-125)

103(73-147)

0.005

HbA1c %

8.1(4.5-13.9)

8.0(5.0-11.1)

8.2(4.5-13.4)

0.61

ACEI/ARBs, n/n (%)

5/0 (11.4%)

9/15 (53.3%)

20/16 (76.6%)

<0.001

CV-Mortality rate per patient-year

0.003994674

0.0110957

0.035836177

<0.001

Renal failure rate per patient-year

0

0.007407

0.032895

<0.001


Abbreviations: ACEI: Angiotensin converting enzyme inhibitors; ARBs: Angiotensin II receptor antagonists; CV: cardiovascular; ESRD: End stage renal disease; GFR: glomerular filtration rate; HbA1c: glycosylated hemoglobin; MAP: Mean arterial blood pressure.

Tofik et al. BMC Medicine 2009 7:39   doi:10.1186/1741-7015-7-39

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