Cumulative analysis of contrast-induced nephropathy. This figure depicts the summary odds ratios of all trials published (in the literature or as an abstract) up to a time point in chronologic order. The odds ratios increase over time illustrating that earlier trials found more pronounced effects of sodium bicarbonate than subsequent studies, while the confidence intervals have narrowed suggesting greater reliability of the effect estimate. Horizontal bars, 95% confidence interval.
Meier et al. BMC Medicine 2009 7:23 doi:10.1186/1741-7015-7-23