Table 2

Subjects are presented according to the method of ascertainment, with the number of unaffected relatives genotyped for LRRK2 mutations shown in parenthesis

Ascertainment method

Subjects (unaffected relatives)

Families

LRRK2 mutations (%)

LRRK2 families (%)


Total familial Parkinson's disease cases and families studied

903 (58)

509

58 (6.4%)

31 (6.1%)

• Affected siblings

730 (37)

401

47 (6.4%)

24 (6.0%)

• Affected parent-offspring

141 (20)

88

11 (7.8%)

7 (8.0%)

• Other affected relatives

32 (1)

20

0

0

Randomly ascertained PD

126

126

6 (4.8%)

6 (4.8%)

Controls

197

197

0

0


No controls or unaffected family members were determined to be LRRK2 carriers.

Latourelle et al. BMC Medicine 2008 6:32   doi:10.1186/1741-7015-6-32

Open Data