Table 2 |
||||
|
Subjects are presented according to the method of ascertainment, with the number of unaffected relatives genotyped for LRRK2 mutations shown in parenthesis |
||||
|
Ascertainment method |
Subjects (unaffected relatives) |
Families |
LRRK2 mutations (%) |
LRRK2 families (%) |
|
|
||||
|
Total familial Parkinson's disease cases and families studied |
903 (58) |
509 |
58 (6.4%) |
31 (6.1%) |
|
• Affected siblings |
730 (37) |
401 |
47 (6.4%) |
24 (6.0%) |
|
• Affected parent-offspring |
141 (20) |
88 |
11 (7.8%) |
7 (8.0%) |
|
• Other affected relatives |
32 (1) |
20 |
0 |
0 |
|
Randomly ascertained PD |
126 |
126 |
6 (4.8%) |
6 (4.8%) |
|
Controls |
197 |
197 |
0 |
0 |
|
|
||||
|
No controls or unaffected family members were determined to be LRRK2 carriers. |
||||
|
Latourelle et al. BMC Medicine 2008 6:32 doi:10.1186/1741-7015-6-32 |
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