miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

doi:10.1186/1741-7015-6-14

BMC Medicine

Volume 6

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Silber J
Lim DA
Petritsch C
Persson AI
Maunakea AK
Yu M
Vandenberg SR
Ginzinger DG
James CD
Costello JF
Bergers G
Weiss WA
Alvarez-Buylla A
Hodgson JG

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Silber J
Lim DA
Petritsch C
Persson AI
Maunakea AK
Yu M
Vandenberg SR
Ginzinger DG
James CD
Costello JF
Bergers G
Weiss WA
Alvarez-Buylla A
Hodgson JG
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Research article

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

Joachim Silber¹ , Daniel A Lim¹^* , Claudia Petritsch¹^* , Anders I Persson²^,3^* , Alika K Maunakea¹ , Mamie Yu¹ , Scott R Vandenberg⁴ , David G Ginzinger⁵ , C David James¹ , Joseph F Costello¹ , Gabriele Bergers¹ , William A Weiss²^,3 , Arturo Alvarez-Buylla¹ and J Graeme Hodgson¹

¹Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA

²Department of Neurology, University of California San Francisco, San Francisco, CA, USA

³Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA

⁴Department of Pathology, University of California San Francisco, San Francisco, CA, USA

⁵Applied Biosystems, Foster City, CA, USA

author email corresponding author email* Contributed equally

BMC Medicine 2008, 6:14doi:10.1186/1741-7015-6-14


Published:	24 June 2008

Additional files

Additional file 1:

Characteristics of the patient tissues used in this study.

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Additional file 2:

Validation of miR-124 expression and function in glioblastoma multiforme cells.

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Additional file 3:

Supplementary methods. This pdf file provides further details related to the methods used in this study.

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Additional file 4:

Log2 fold change of microRNAs in non-tumor brain samples (glioses), anaplastic astrocytomas and glioblastoma multiforme tumors.

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Additional file 5:

Validation of let-7a and miR-16 as appropriate control miRNAs in primary tumor samples and neural stem cells.

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Additional file 6:

Statistical comparisons of miRNA expression in glioblastoma multiforme and anaplastic astrocytoma tumors versus non-tumor brain tissue (gliosis).

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Additional file 7:

Assessment of miR-124a and miR-137 expression in mouse oligodendroglial stem cells.

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Additional file 8:

miR expression in glioblastoma multiforme cell lines following treatment with DNA demethylating and deacetylating agents

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