Table 2

Models used for analysis of the effects of statins on incidence of dementia using the Cox proportional survival method.

Model 1

Model 2

Model 3


Variable

HR

p value

95% Confidence limits for HR

HR

p value

95% Confidence limits for HR

HR

p value

95% Confidence limits for HR


Atorvastatin

Versus CV

0.80

0.0005

0.71

0.91

0.90

0.09

0.79

1.02

0.91

0.11

0.80

1.02

Age

1.11

<0.0001

1.10

1.12

1.11

<0.0001

1.10

1.11

Hypertension

1.10

0.0590

1.00

1.20

CVD

1.13

0.0005

1.05

1.20

Diabetes

1.12

0.0009

1.05

1.20

Charlson Index

1.78

<0.0001

1.66

1.91

Lovastatin

Versus CV

0.98

0.70

0.89

1.08

0.95

0.32

0.86

1.05

0.95

0.34

0.86

1.05

Age

1.11

<0.0001

1.10

1.12

1.11

<0.0001

1.10

1.11

Hypertension

1.09

0.07

0.99

1.19

CVD

1.12

0.0005

1.05

1.20

Diabetes

1.12

0.0009

1.05

1.20

Charlson Index

1.74

<0.0001

1.62

1.86

Simvastatin

Versus CV

0.45

<0.0001

0.43

0.47

0.45

<0.0001

0.43

0.48

0.46

<0.0001

0.44

0.48

Age

1.11

<0.0001

1.10

1.11

1.11

<0.0001

1.10

1.11

Hypertension

1.07

0.07

1.00

1.15

CVD

1.09

0.0012

1.04

1.15

Diabetes

1.08

0.0034

1.03

1.14

Charlson Index

1.72

<0.0001

1.63

1.81


HR, hazard ratio, CVD, cardiovacular disease, CV, cardiovascular.

Model 1 included an adjustment for the interaction between dementia and age; model 2 included adjustments for the interaction between dementia and three disorders associated with increased risk of dementia.; model 3 included adjustments for the interaction between dementia and the Charlson Index, which is an index that provides a broad assessment for the amount of chronic disease. For the purpose of analysis of interactions with the Charlson Index, subjects with a Charlson Index of 0 or 1 were compared with those with a Charlson Index of ≥2.

Wolozin et al. BMC Medicine 2007 5:20   doi:10.1186/1741-7015-5-20

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