|
Blood pressure, heart rate and lipid levels in different genotypes of the β2-adrenergic receptor polymorphisms. |
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| n |
SBP mmHg |
DBP mmHg |
HR beats/min |
n |
Cholesterol mg/dl |
Triglycerides mg/dl |
n |
HDL mg/dL |
LDL mg/dL |
|
|
|
||||||||||
| All |
429 |
130.5 ± 15.7 |
79.6 ± 9.2 |
76.8 ± 9.5 |
360 |
224.7 ± 39.4 |
171.5 ± 95.7 |
278 |
46.8 ± 14.3 |
146.6 ± 35.9 |
| Codon -47 |
||||||||||
| Cys/Cys |
131 |
130 ± 1 ± 16.3 |
79.8 ± 9.4 |
77.0 ± 9.1 |
112 |
226.0 ± 40.3 |
168.6 ± 76.5 |
93 |
46.0 ± 14.3 |
148.9 ± 32.9 |
| Cys/Arg |
195 |
130.9 ± 15.6 |
79.6 ± 9.3 |
76.6 ± 8.9 |
163 |
222.5 ± 38.5 |
175.3 ± 102.5 |
123 |
47.3 ± 13.9 |
144.0 ± 38.6 |
| Arg/Arg |
103 |
130.1 ± 15.1 |
79.4 ± 8.7 |
76.9 ± 11.0 |
85 |
227.6 ± 40.1 |
167.9 ± 105.2 |
62 |
46.9 ± 15.5 |
148.3 ± 35.1 |
| P |
0.878 |
0.942 |
0.924 |
0.594 |
0.789 |
0.796 |
0.578 |
|||
| Codon 16 |
||||||||||
| Arg/Arg |
59 |
133.6 ± 17.2 |
80.9 ± 9.3 |
78.4 ± 9.3 |
53 |
228.2 ± 45.7 |
178.5 ± 114.2 |
39 |
49.7 ± 15.9 |
149.5 ± 34.8 |
| Arg/Gly |
197 |
130.0 ± 15.9 |
79.8 ± 9.5 |
76.6 ± 9.4 |
158 |
221.4 ± 38.6 |
164.7 ± 92.5 |
123 |
47.0 ± 14.4 |
143 ± 37.2 |
| Gly/Gly |
173 |
129.9 ± 14.9 |
79.0 ± 8.9 |
76.5 ± 9.7 |
149 |
227.2 ± 37.8 |
176.0 ± 91.8 |
116 |
45.7 ± 13.8 |
149.4 ± 34.9 |
| P |
0.268 |
0.389 |
0.371 |
0.345 |
0.496 |
0.305 |
0.348 |
|||
| Codon 27 |
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| Gln/Gln |
109 |
130.7 ± 14.5 |
80.2 ± 9.0 |
77.2 ± 9.2 |
93 |
222.7 ± 42.3 |
175.9 ± 89.4 |
74 |
44.9 ± 14.0 |
145.6 ± 32.9 |
| Gln/Glu |
202 |
130.8 ± 15.2 |
79.2 ± 9.1 |
76.6 ± 9.2 |
164 |
225.3 ± 38.3 |
174.1 ± 100.9 |
128 |
47.2 ± 14.3 |
146.5 ± 38.2 |
| Glu/Glu |
118 |
130.5 ± 15.7 |
79.9 ± 9.5 |
76.8 ± 10.2 |
103 |
224.8 ± 39.4 |
163.3 ± 93.0 |
76 |
48.0 ± 14.8 |
147.8 ± 35.2 |
| P |
0.840 |
0.592 |
0.859 |
0.841 |
0.585 |
0.395 |
0.930 |
|||
|
Comparison of blood pressure, heart rate, lipid and lipoprotein values between the different genotypes of the β2-adrenergic receptor polymorphisms in untreated patients with OSA. Total cholesterol and triglyceride levels were available for 360 patients and lipid electrophoresis for 278 patients. There were no significant differences between the genotypes. SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; HR, heart rate; LDL, low-density lipoprotein. | ||||||||||
Bartels et al. BMC Medicine 2007 5:1 doi:10.1186/1741-7015-5-1 |
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