Additional File 2.

Col1a1tmJae mice possess collagen dense mammary tissue. Histology of homozygous col1a1 mice (A) showing increased collagen surrounding the mammary duct as detected with H&E trichrome, and picrosirius red (Picro) staining. (B) Increased collagen is also present in heterozygous col1a1 mice as detected with H&E; and picrosirius red staining (PS).

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Provenzano et al. BMC Medicine 2006 4:38   doi:10.1186/1741-7015-4-38