Research article
Collagen reorganization at the tumor-stromal interface facilitates local invasion
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* Corresponding authors: Paolo P Provenzano paolo.provenzano@gmail.com - Patricia J Keely pjkeely@wisc.edu
BMC Medicine 2006, 4:38 doi:10.1186/1741-7015-4-38
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Collagen density promotes mammary tumor initiation and progression Paolo P Provenzano, David R Inman, Kevin W Eliceiri, Justin G Knittel, Long Yan, Curtis T Rueden, John G White, Patricia J Keely BMC Medicine 2008, 6:11 (28 April 2008) Increased stromal collagen density in mouse mammary tissue increases both tumor formation and tumor cell invasive and migratory properties by three fold; furthermore, a metabolic signature for flavin adenine dinucleotide is identified in invading metastatic cells.
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Review
Lisa J Martin, Norman F Boyd Breast Cancer Research 2008, 10:201 (9 January 2008) This article is part of a collection on Mammographic density |
