|
Demographic and clinical characteristics at baseline for patients with a major depressive episode (full analysis set) |
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| Characteristic |
WS® 5570 600 mg/day N = 119 |
WS® 5570 1200 mg/day N = 124 |
Placebo N = 81 |
p-value |
|
|
|
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| Sex: |
0.13* |
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| Female |
n (%) |
67 (56.3) |
82 (66.1) |
56 (69.1) |
|
| Male |
n (%) |
52 (43.7) |
42 (33.9) |
25 (30.9) |
|
| Age (years) |
Mean ± SD |
46.3 ± 11.5 |
46.1 ± 10.7 |
46.9 ± 11.8 |
0.69§ |
| HAM-D total score |
Mean ± SD |
22.8 ± 3.3 |
22.6 ± 3.8 |
23.6 ± 4.2 |
0.31 |
| CGI severity of illness: |
0.20* |
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| Mildly or moderately ill |
n (%) |
67 (56.3) |
62 (50.0) |
46 (56.8) |
|
| Markedly or severely ill |
n (%) |
52 (43.7) |
62 (50.0) |
35 (43.2) |
|
| MADRS |
Mean ± SD |
27.2 ± 5.5 |
26.3 ± 6.0 |
28.0 ± 6.2 |
0.09§ |
| BDI |
Mean ± SD |
23.2 ± 7.9 |
23.3 ± 8.0 |
25.7 ± 8.9 |
0.05§ |
| SF-36 summary measure mental health |
Mean ± SD |
25.1 ± 11.7 |
27.7 ± 13.3 |
23.7 ± 11.1 |
0.16§ |
|
For the HAM-D, MADRS and BDI, a higher value indicates more severe impairment whereas for the SF-36, a lower score indicates more severe impairment. *Two-sided chi-square test §Two-sided Kruskal-Wallis test | |||||
Kasper et al. BMC Medicine 2006 4:14 doi:10.1186/1741-7015-4-14 |
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