Table 1

Studies included in this systematic review.

Treatment Approach

Number of Trials

Reference Numbers

Summary of Results


Randomized Controlled Trials

Preoperative RT v. Surgery Alone

6

5*,21–25†

Table 2

Postoperative RT v. Surgery Alone

4

5*,27–29,47

Table 3

Preoperative RT v. Postoperative RT

1

5*

-

Preoperative RT + Postoperative RT v. Postoperative RT

1

30

-

Preoperative CT v. Surgery Alone

6

24†,32–35,37,48

Table 4

Preoperative + Postoperative CT v. Surgery Alone

2

31,36

Table 5

Postoperative CT v. Surgery Alone

3

39–41

Table 6

Preoperative CRT v. Surgery Alone

6

24†,42–46,51–53

Table 7

Postoperative CT v. Postoperative RT

1

56

-

Preoperative CT v. Preoperative RT

2

24†,57

-

Preoperative CRT v. Preoperative RT

1

58

-

Postoperative Immunotherapy with RT or CRT v. RT or CRT

1

59

-

Preoperative Hyperthermia with CRT v. preoperative CRT

1

60

-

Meta-analyses

Preoperative RT v. Surgery Alone

1

26

-

Preoperative CT v. Surgery Alone

2

38,49,50

-

Preoperative CRT v. Surgery Alone

2

54,55

-


Note: CT indicates chemotherapy; CRT, chemoradiation; RT, radiotherapy; v., versus.

* The four-arm trial by Fok et al [5] contributed to three comparisons.

† The four-arm trial by Nygaard et al [24] contributed to four comparisons.

‡ Reports published in abstract form only [35,41,51,53,54].

Malthaner et al. BMC Medicine 2004 2:35   doi:10.1186/1741-7015-2-35

Open Data