Table 3

Quantitative gene (mRNA) expression data in ventricular samples from a background of no cardiac disease (Control), idiopathic cardiomyopathy (IDC) and ischemic cardiomyopathy (ICM).

Target

Copy number with 95% CI


Control

(n = 9)

IDC

(n = 11)

Δ from

Control

ICM

(n = 12)

Δ from Control

ACE2

3,978

(2,102–5,531)

9,612†

(5,873–15,734)

2.4

7,338†

(5,304–10,153)

1.8

ACE

720

(349–1,484)

2,239†

(1,343–3,735)

3.1

1,692†

(1,295–2,211)

2.4

ANF

19,547

(4,377–87,287)

248,243†

(57,940–10,635,486)

12.7

151,551

(57,743–397,759)

7.8

AT1

623

(456–850)

594

(347–1,020)

0.95

541

(352–829)

0.87

RENIN

0

0

0


Values are geometric mean copy number for each gene/100 ng total RNA. † – P < 0.05 disease group Vs. Control.

Goulter et al. BMC Medicine 2004 2:19   doi:10.1186/1741-7015-2-19

Open Data