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Open Access Highly Accessed Research article

A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis

Philippe Devillier12*, Jean-François Dreyfus2, Pascal Demoly3 and Moisés A Calderón4

Author Affiliations

1 UPRES EA 220 & Clinical Research Department, Foch Hospital, University of Versailles Saint-Quentin, Suresnes, France

2 Biostatistics Unit, Clinical Research Department, Foch Hospital, Suresnes, France

3 EPAR INSERM U707, Allergy Division, Pulmonology Department, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France, and Institut Pierre Louis d’Epidémiologie et de Santé Publique, Faculté de Médecine, Université Pierre et Marie Curie, Paris, France

4 Section of Allergy and Clinical Immunology, Imperial College London-NHLI, Royal Brompton Hospital, Dovehouse Street, London, UK

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BMC Medicine 2014, 12:71  doi:10.1186/1741-7015-12-71

Published: 1 May 2014

Additional files

Additional file 1: Table S1:

List of studies initially considered but not selected, together with the reasons for non-selection.

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Additional file 2: Table S2:

Pharmacotherapy and grass pollen SLIT tablet trials in seasonal allergic rhinitis. TnNSS: total nasal symptom score with n symptoms; TnSS: total symptom score with n symptoms; TnOSS: total ocular symptom score with n symptoms; QD: once daily, BID; twice daily; IR: index of reactivity; SQ-T: standardized quality tablet. RTSS: rhinoconjunctivitis total symptom score; as used in the meta-analysis; *as used in the meta-analysis and generally (but not always) the study's stated primary efficacy criterion.

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Additional file 3: Table S3:

RCI and meta-analysis of efficacy (based on combined scores) for grass pollen SLIT tablets. N Act: number of subjects in the active treatment group; Mean Act: mean score in the active treatment group; SD Act; standard deviation for the score in the active treatment group; N Plac: number of subjects in the placebo group; Mean Plac: mean score in the placebo group; SD Plac: standard deviation for the score in the placebo group; RCI: relative clinical impact; hg: Hedges' g; ci-: lower confidence interval; ci+: upper confidence interval; z: z score: p: P-value; w: weighting; ACS: average combined score; TCS: total combined score = daily symptom score + daily medication score; WCS: weighted combined score = (daily symptom score/maximum symptom score))/(1- daily medication score - maximum symptom score).

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Additional file 4: Table S4:

Methodological differences in the evaluation of treatments for pollen-induced seasonal allergic rhinitis. T6SS: total symptom score with six individual symptoms; T4SS: total symptom score with four individual symptoms.

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Open Data