Table 2

Relationship between estimated glomerular filtration rate and death or the necessity of renal replacement therapy
Estimated glomerular filtration rate (mL/min)
>90 60 to 90 45 to 60 30 to 45 <30 P
MDRD events 8/72 43/232 34/129 30/76 16/30
HR1 0.60 1 1.44 2.12 3.34 0.000
(0.28 to 1.28) (0.90 to 2.29) (1.30 to 3.45) (1.87 to 5.99)
HR2 0.60 1 1.35 2.03 3.32 0.000
(0.28 to 1.28) (0.85 to 2.15) (1.25 to 3.30) (1.82 to 6.05)
CKD-EPIcreat events 3/9 46/288 35/126 24/78 23/38
HR1 2.76 1 1.77 1.83 4.89 0.000
(0.84 to 9.01) (1.12 to 2.78) (1.09 to 3.05) (2.93 to 8.17)
HR2 3.01 1 1.65 1.72 5.04 0.000
(0.91 to 9.96) (1.05 to 2.61) (1.03 to 2.88) (2.95 to 8.60)
CKD-EPIcyst events 4/36 13/97 29/152 32/148 53/106
HR1 0.81 1 1.29 1.44 3.49 0.000
(0.27 to 2.50) (0.67 to 2.50) (0.75 to 2.75) (1.87 to 6.50)
HR2 0.76 1 1.19 1.43 3.41 0.000
(0.25 to 2.36) (0.61 to 2.32) (0.75 to 2.75) (1.81 to 6.42)
CKD-EPIcreatcyst events 6/37 22/154 30/157 34/123 39/68
HR1 1.23 1 1.34 1.82 4.14 0.000
(0.49 to 3.04) (0.77 to 2.35) (1.05 to 3.17) (2.39 to 7.15)
HR2 1.14 1 1.30 1.76 4.29 0.000
(0.46 to 2.88) (0.74 to 2.30) (1.01 to 3.09) (2.41 to 7.63)
BIS event/total 2/4 13/104 36/215 45/160 35/56
HR1 4.63 1 1.26 2.01 5.09 0.000
(1.04 to 20.57) (0.67 to 2.39) (1.08 to 3.77) (2.66 to 9.76)
HR2 4.75 1 1.31 1.98 5.58 0.000
(1.06 to 21.25) (0.69 to 2.50) (1.05 to 2.50) (2.84 to 10.96)

HR1, Hazard ratio for model 1 - adjusted for age and gender; HR2, Hazard ratio for model 2 - adjusted for age, gender, hypertension, diabetes mellitus, history of a serious cardiovascular event and smoking status.

Van Pottelbergh et al.

Van Pottelbergh et al. BMC Medicine 2014 12:27   doi:10.1186/1741-7015-12-27

Open Data